Doktorské studium

Studijní obor Strukturní biologie

Název práce: Multiscale Modeling of Nucleic Acids

Školitel: prof. RNDr. Jiří Šponer, DrSc.

Oficiální zadání:
Nucleic acids (RNA and DNA) belong to the most important biomacromolecules. Studies of structure and dynamics of nucleic acids represent an important task of modern life sciences. Due to fast development of hardware and software, computational and theoretical approaches are frequently used in nucleic acids studies and represent a respected counterpart of experimental techniques. This PhD project will be based on integrated interdisciplinary utilization of a broad spectrum of computational methods (multi-scale modelling) ranging from state-of-the-art quantum-chemical (QM) approaches through modern explicit solvent molecular dynamics (MD) simulation methods up to bioinformatics. Cooperation with established experimental laboratories will provide necessary experimental feedback. State-of-the-art computational facilities are available not only in our laboratory but also in cooperating laboratories abroad. The exact topic will be specified based on the discussion with the applicant and her/his scientific interests and capabilities. Currently available specific themes include for example multiscale studies of protein-RNA complexes, RNA catalysis, structural dynamics and folding of quadruplex DNA and large-scale QM studies of complete nucleic acids building blocks.


login
© 2011 Přírodovědecká fakulta Masarykovy univerzity. tel: +420 549 49 1111, e-mail:
Všechna práva vyhrazena.
Webmaster: Alan Kuběna,
Grafický design: © 2011 Mgr. Pavel Brabec,
Obsahová struktura: © 2011 Mgr. Zuzana Kobíková
Počet přístupů: 514143 od 2.9.2011