Department of Experimental Biology

Research and Educational Activities

Research activities at the Department of Experimental Biology include the following areas:
  • Principles of proliferation, differentiation and programmed cell death in cancer cells with emphasis on the role of the Myb protein family in these processes.
  • Cell signalling pathways controlling cell proliferation, differentiation and cell death triggered by specific endogenous factors and cytokines (FGF, Wnt, TNF, TGF) and their interactions with lipids in normal and cancer cells
  • Analysis of chromosomal aberrations relevant to tumor progression and their use in diagnosis and prognosis of cancer diseases.
  • The role of procathepsin D in cancer progression.
  • Molecular mechanisms regulating differentiation of osteoclasts.
  • Cellular and molecular factors of insect immunity, molecular basis of insect magnetoreception, and some aspects of immune processes induced by pathogenic microorganisms.
  • Inflammation and principles of formation of reactive oxygen and nitrogen species by phagocytes during a stress.
  • Principles of formation of reactive oxygen species during a stress and quantification of photoprotective mechanisms activated in pigment-protein complexes of chloroplastic thylakoid membranes.
  • Ecophysiological research of Antarctic vegetation oases (James Ross Island).
  • Molecular diagnostics and genomics of pathogenic bacteria (especially of clinically important species of Staphylococcus).
  • Principles of interactions between staphylococcal strains and bacteriophages.
  • Development of novel diagnostic methods for molecular epidemiology and taxonomy of staphylococci.
  • Biology of selected zoonotic microorganisms, including viruses
  • Use of magnetic nano- and microparticles with immobilized selective ligands in DNA diagnostics of bacteria
  • Development of methods for evaluation and rapid detection of selected lactic acid bacteria and bifidobacteria in complex matrices
  • Environmental factors and metabolism of microbes
  • Application of molecular methods in microbial ecology
  • Study of bacterial proteome
  • Application of automated and semiautomated methods for identification and characterization of new bacterial strains with probiotic features aiming to extend specific genetic resources for prevention of civilizational diseases
  • Fundamental principles of enzymatic catalysis and development of enzymes for environmental, chemical and biomedical applications.
  • Principles of regulation of metabolism, growth and differentiation of cells and tissues by functional analyses of selected genes and complete genomes. Description of structure and function of indispensable chromosome elements, e.g. centromeres and telomeres.
  • Molecular and developmental biology of plant hormonal regulations, plant functional genomics and proteomics.
  • Examination of biological traits of human population (from historical skeletal samples up to recent living humans) with a special attention to exploration of historical genetic information (so- called ancient DNA).
Department of Experimental Biology is a guarantee of three study programs within the field of Biology at the Bachelor, Master and Doctoral levels. The Bachelor studies include Cellular and Molecular Diagnostics, General Biology, Molecular Biology and Genetics. The Master studies include General Biology with four specializations (Plant Physiology, Animal Physiology, Microbiology and Ecotoxicology) and Molecular Biology. At the postgraduate level, the Department offers education in the following fields: Anatomy and Physiology of Plants, Animal Physiology, Microbiology, Molecular and Cellular Biology, General and Molecular Genetics, Genomics and proteomics.
  • Laboratory of Microbial Molecular Diagnostics
  • Laboratory of Cell Differentiation
  • Laboratory of Tumor Biology and Genetics
  • Laboratory of Molecular Cytogenetics
  • Laboratory of Biological and Molecular Anthropology
  • Laboratory of Plant Molecular Genetics
  • Laboratory of Microbial Molecular Biotechnology
  • Laboratory of Zoonotic Microorganisms
  • Laboratory of Environmental Microbiology
  • Czech Collection of Microorganisms
  • Laboratory of Cell Signalling
  • Laboratory of Immunology
  • Laboratory of Insect Neuroetology
  • Laboratory of Photosynthetic Processes
  • Laboratory of Experimental Histochemistry and Mycorrhiza
  • Laboratory of Plant Stress Physiology
  • Laboratory of Analysis of Biologically Important Molecular Complexes
  • Laboratory of Molecular Plant Physiology
  • Loschmidt Laboratories

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