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Photoactivatable Compounds
Photoactivatable compounds, also called caged compounds, are
those which, upon photoactivation, either (1) irreversibly release a species
possessing desirable physical, chemical, or biological qualities, while the
groups that are responsible for the photoprocess are referred to as
photoremovable, photoreleasable or photolabile, or (2) reversibly induce
physical or chemical changes in another, covalently or non-covalently bound
moiety - in this case, they are called photochemical switches and the
process is usually termed as photochromic. Today photoactivatable compounds
are of a great interest in connection with biochemical and biological
applications (such as photoregulation of proteins and enzyme activity or
neurotransmitters delivery), organic synthesis (e.g., photoremovable protecting groups;
solid-phase synthesis; microarray fabrication), nanotechnology (prospective
molecular machines and computers), or cosmetics (photoactivatable fragrances).
A great advantage of photochemical activation over other stimuli is the
ability to precisely control the processes in time and space.
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Kammari L., Šolomek T.,
Ngoy B. P., Heger D., Klán P.,
Orthogonal Photocleavage of a Monochromophoric Linker, J. Am. Chem. Soc.
2010, 132, 11431–11433.
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Šolomek T., Štacko P.,
Tazhe Veetil A., Pospíšil T., Klán P.,
Photoenolization-Induced Oxirane Ring Opening in 2,5-Dimethylbenzoyl Oxiranes to Form Pharmaceutically Promising
Indanone Derivatives,
J. Org. Chem. 2010, 75, 7300–7309.
Kinetic
Flash Photolysis and Reaction
Mechanisms
Flash and
pump-and-probe photolysis is the most important
tool to produce transient intermediates in sufficient concentration for time-resolved
spectroscopic detection and for the identification of elementary reaction
steps. Our flash photolysis
system
can perform transient absorption measurements within the range of 100 fs to
1 ms.
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Plistil L., Solomek T., Wirz J.,
Heger, D., Klán P.,
Photochemistry of 2-Alkoxymethyl-5-methylphenacyl Chloride and Benzoate,
J. Org. Chem. 2006, 71, 8050-8058.
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Pelliccioli A.
P., Klán P., Zabadal M., Wirz J.,
Photorelease of HCl from o-Methylphenacyl Chloride Proceeds through the Z-xylylenol,
J. Am. Chem. Soc.
2001,
123, 7931-7932.
Photochemistry of
Organic Compounds in
Ice and Snow
Ultraviolet light is
effective at promoting photochemical and post-irradiation reactions in
ice/snow. For example, photolysis of the organic compounds accumulated in
snow appears to have an impact on the composition of the lower atmosphere in
early polar spring. Study of the chemical effects resulting
from the irradiation of ice/snow field samples or laboratory-produced frozen
aqueous solutions with UV light is now an active research area relevant to
atmospheric chemical processes taking place in high latitude environments
and related ice and snow environments.
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Kurková R., Ray D.,
Nachtigallová D., Klán P.,
Chemistry of Small Organic Molecules on Snow Grains: The Applicability of Artificial Snow for Environmental Studies, Environ. Sci. Technol. 2011, 45,
3430–3436.
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Heger D., Jirkovsky J., Klán P.,
Aggregation of Methylene Blue in Frozen Aqueous Solutions Studied by
Absorption Spectroscopy,
J. Phys. Chem. A
2005,
109, 6702-6709.
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