Publications

2019

Karol Kaiser, Daniel Gyllborg, Jan Procházka, Alena Salašová, Petra Kompaníková, Francisco Lamus Molina, Rocio Laguna-Goya, Tomasz Radaszkiewicz, Jakub Harnoš, Michaela Procházková, David Potěšil, Roger A. Barker, Ángel Gato Casado, Zbyněk Zdráhal, Radislav Sedláček, Ernest Arenas, J. Carlos Villaescusa & Vítězslav Bryja, 2019: WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nature Comm: 10(1):1498.

Kotrbová A., Štěpka K., Maška M., Pálenik JJ., Ilkovics L., Klemová D., Kravec M., Hubatka F., Dave Z., Hampl A., Bryja V., Matula P., Pospíchalová V., 2019: TEM ExosomeAnalyzer: a computer-assisted software tool for quantitative evaluation of extracellular vesicles in transmission electron microscopy images. J Extracell Vesicles: -.

Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukáš Trantírek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann & Vítězslav Bryja, 2019: Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1. Nature Communications: 10: 1804.

2018

Plešingerová H, Janovská P, Mishra A, Smyčková L, Poppová L, Libra A, Plevová K, Ovesná P, Radová L, Doubek M, Pavlová Š, Pospíšilová Š, Bryja V., 2018: Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia.. Haematologica: 103(2):313-324.

Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte, 2018: Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization. J Biol Chem: 18477-18493.

Harnoš J, Ryneš J, Víšková P, Foldynová-Trantírková S, Bajard-Ešner L, Trantírek L, Bryja V, 2018: Analysis of AXIN1 binding interfaces by peptide microarrays. J Biol Chem: 16337-16347.

Lee Y, Kim NH, Cho ES, Yang JH, Cha YH, Kang HE, Yun JS, Cho SB, Lee SH, Paclikova P, Radaszkiewicz TW, Bryja V, Kang CG, Yuk YS, Cha SY, Kim SY, Kim HS, Yook JI, 2018: Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Nat Commun: -.

Remco A. Mentink, Lorenzo Rella, Tomasz W. Radaszkiewicz, Tomáš Gybel, Marco C. Betist, Vitězslav Bryja, Hendrik C. Korswagen, 2018: The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism. PLOS Genetics: -.

Janovska P.; Verner J.; Kohoutek J.; Bryjova L.; Gregorova M.; Dzimkova M.; Skabrahova H.; Radaszkiewicz T.; Ovesna P.; Vondalova Blanarova O.; Nemcova T.; Hoferova Z; Vasickova K.; Smyckova L.; Egle A.; Pavlova S.; Poppova L.; Plevova K.; Pospisilova S.; Bryja V., 2018: Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia. Blood: -.

2017

Bryja V., Červenka I, Čajánek L., 2017: The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?. Crit Rev Biochem Mol Biol.: 25:1-4.

Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, Bryja V, Lendahl U., 2017: Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.. Gastroenterology: S0016-5085(17)36336-9 Epub ahead of print.

Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M., 2017: Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.. PLoS One: 12(12):e0188772.

Fatima I, El-Ayachi I, Taotao L, Lillo MA, Krutilina R, Seagroves TN, Radaszkiewicz TW, Hutnan M, Bryja V, Krum SA, Rivas F, Miranda-Carboni GA., 2017: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer.. PLoS One: 12(12):e0189864.

Schulte G, Bryja V., 2017: WNT signalling: mechanisms and therapeutic opportunities.. Br J Pharmacol.: 4543-4546.

Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G., 2017: The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.. Cell Signal.: 38:85-96.

Janovská P, Bryja V., 2017: WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas.. Br J Pharmacol.: 174(24):4701-4715.

Salašová A, Yokota C, Potěšil D, Zdráhal Z, Bryja V., Arenas E., 2017: A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.. Mol Neurodegener.: 12(1):54..

Paclíková P, Bernatík O, Radaszkiewicz TW, Bryja V., 2017: N-terminal part of Dishevelled DEP domain is required for Wnt/β-catenin signaling in mammalian cells.. Mol Cell Biol.: [Epub ahead of print].

Bernatik O, Radaszkiewicz T, Behal M, Dave Z, Witte F, Mahl A, Cernohorsky NH, Krejci P, Stricker S, Bryja V., 2017: A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.. Front Cell Dev Biol.: 5:47.

Putnová I, Dosedělová H, Bryja V., Landová M, Buchtová M, Štembírek J., 2017: Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6.. Front Physiol.: 8:29.

H. Plešingerová, Z. Librová, K. Plevová, A. Libra, B. Tichý, H. Skuhrová-Francová, F. Vrbacký, L. Smolej, J. Mayer, V. Bryja, M. Doubek, Šárka Pospíšilová, 2017: COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status.. Leuk Lymphoma: 58(1):70-79.

F. Linke, S. Zaunig, M. M. Nietert, F. von Bonin, S. Lutz, C. Dullin, P. Janovská, T. Beissbarth, F. Alves, V. Bryja, T. Pukrop, L. Trümper, J. Wilting, D. Kube, 2017: WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene: 36(1):13-23.

K. Štěpka, M. Maška, J. J. Pálenik, V. Pospíchalová, A. Kotrbová, L. Ilkovics, D. Klemová, A. Hampl, V. Bryja, P. Matula, 2017: Automatic Detection and Segmentation of Exosomes in Transmission Electron Microscopy. Computer Vision – ECCV 2016 Workshops. ECCV 2016. Lecture Notes in Computer Science: -.

Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D., 2017: Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.. Leukemia: 31(2):361-372.

2016

Kotašková J, Pavlová Š, Greif I, Stehlíková O, Plevová K, Janovská P, Brychtová Y, Doubek M, Pospíšilová Š, Bryja V., 2016: ROR1-based immunomagnetic protocol allows efficient separation of CLL and healthy B cells. Br J Haematol.: 175(2):339-342.

L. Poppova, P. Janovska, K. Plevova, L. Radova, H. Plesingerova, M. Borsky, J. Kotaskova, B. Kantorova, M. Hlozkova, J. Figulova, Y. Brychtova, M. Machalova, M. Urik, M. Doubek, A. Kozubik, S. Pospisilova, S.Pavlova, V. Bryja, 2016: Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV. Br J Haematol.: 175(5):851-859.

I. Cervenka, J. Valnohova, O. Bernatik, J. Harnoš, M. Radsetoulal, K. Sedova, K. Hanakova, D. Potesil, M. Sedlackova, A. Salasova, Z. Steinhart, S. Angers, G. Schulte, A. Hampl, Z. Zdrahal, V. Bryja., 2016: Dishevelled is a NEK2 substrate controlling dynamics of centrosomal linker proteins.. Proc Natl Acad Sci USA: 113(33):9304-9.

Janovska P, Poppova L, Plevova K, Plesingerova H, Behal M, Kaucka M, Ovesna P, Hlozkova M, Borsky M, Stehlikova O, Brychtova Y, Doubek M, Machalova M, Baskar S, Kozubik A, Pospisilova S, Pavlova S, Bryja V., 2016: Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia.. Clin Cancer Res.: 22(2):459-69.

Zemanova J, Hylse O, Collakova J, Vesely P, Oltova A, Borsky M, Zaprazna K, Kasparkova M, Janovska P, Verner J, Kohoutek J, Dzimkova M, Bryja V, Jaskova Z, Brychtova Y, Paruch K, Trbusek M., 2016: Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells. Oncotarget: 7(38):62091-62106.

2015

Pospichalova V, Svoboda J, Dave Z, Kotrbova A, Kaiser K, Klemova D, Ilkovics L, Hampl A, Crha I, Jandakova E, Minar L, Weinberger V, Bryja V., 2015: Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer.. J Extracell Vesicles.: 4:25530.

Mo L, Pospichalova V, Huang Z, Murphy SK, Payne S, Wang F, Kennedy M, Cianciolo GJ, Bryja V, Pizzo SV, Bachelder RE., 2015: Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.. PLoS One: 10(7):e0131579.

Buchtova M, Oralova V, Aklian A, Masek J, Vesela I, Ouyang Z, Obadalova T, Konecna Z, Spoustova T, Pospisilova T, Matula P, Varecha M, Balek L, Gudernova I, Jelinkova I, Duran I, Cervenkova I, Murakami S, Kozubik A, Dvorak P, Bryja V, Krejci P., 2015: Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.. Biochim Biophys Acta.: 1852(5):839-50.

Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D, Barboric M., 2015: Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. Nucleic Acids Res.: 43(5):2575-89.

Kaucká M, Petersen J, Janovská P, Radaszkiewicz T, Smyčková L, Daulat AM, Borg JP, Schulte G, Bryja V., 2015: Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway. Cell Commun Signal: 13:2.

2014

Bernatík O, Šedová K, Schille C, Ganji RS, Červenka I, Trantírek L, Schambony A, Zdráhal Z, Bryja V., 2014: Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5.. J Biol Chem.: 289(34):23520-33.

de Groot RE, Ganji RS, Bernatik O, Lloyd-Lewis B, Seipel K, Šedová K, Zdráhal Z, Dhople VM, Dale TC, Korswagen HC, Bryja V., 2014: Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.. Sci Signal.: 7(317):ra26.

Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G., 2014: Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.. FASEB J.: 28(5):2293-305.

Seitz K, Dürsch V, Harnoš J, Bryja V, Gentzel M, Schambony A., 2014: β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation.. PLoS One: 9(1):e87132.

Kríz V, Pospíchalová V, Masek J, Kilander MB, Slavík J, Tanneberger K, Schulte G, Machala M, Kozubík A, Behrens J, Bryja V., 2014: β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.. J Biol Chem.: 289(2):1128-41.

2013

Čajánek L, Ganji RS, Henriques-Oliveira C, Theofilopoulos S, Koník P, Bryja V, Arenas E., 2013: Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.. Mol Cell Biol.: 33(1):59-70.

Soldano A, Okray Z, Janovska P, Tmejová K, Reynaud E, Claeys A, Yan J, Atak ZK, De Strooper B, Dura JM, Bryja V, Hassan BA., 2013: The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.. PLoS Biol.: 11(5):e1001562.

Kaucká M, Plevová K, Pavlová S, Janovská P, Mishra A, Verner J, Procházková J, Krejcí P, Kotasková J, Ovesná P, Tichy B, Brychtová Y, Doubek M, Kozubík A, Mayer J, Pospísilová S, Bryja V., 2013: The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.. Cancer Res.: 73(5):1491-501.

Andersson ER, Saltó C, Villaescusa JC, Cajanek L, Yang S, Bryjova L, Nagy II, Vainio SJ, Ramirez C, Bryja V, Arenas E., 2013: Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells.. Proc Natl Acad Sci U S A.: 110(7):E602-10.

2012

Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F., 2012: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.. Cell: 150(3):533-48.

Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I, Balek L., 2012: Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation.. PLoS One: 7(4):e35826.

Kele J, Andersson ER, Villaescusa JC, Cajanek L, Parish CL, Bonilla S, Toledo EM, Bryja V, Rubin JS, Shimono A, Arenas E., 2012: SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells.. Stem Cells: 30(5):865-75.

2011

Kaucká M, Krejčí P, Plevová K, Pavlová S, Procházková J, Janovská P, Valnohová J, Kozubík A, Pospíšilová S, Bryja V., 2011: Post-translational modifications regulate signalling by Ror1.. Acta Physiol (Oxf): 203(3):351-62.

Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J., 2011: Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.. EMBO J: 30(8):1433-43.

Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V., 2011: Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.. J Biol Chem.: 286(12):10396-410.

Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G., 2011: WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.. Cell Signal.: 23(3):550-4.

Červenka I, Wolf J, Mašek J, Krejci P, Wilcox WR, Kozubík A, Schulte G, Gutkind JS, Bryja V., 2011: Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.. Mol Cell Biol.: 31(1):179-89.

Hrubá E, Vondráček J, Líbalová H, Topinka J, Bryja V, Souček K, Machala M., 2011: Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands.. Toxicol Lett: 206(2):178-88.

Procházková J, Kabátková M, Bryja V, Umannová L, Bernatík O, Kozubík A, Machala M, Vondrácek J., 2011: The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors.. Toxicol Sci.: 122(2):349-60.

Tanneberger K, Pfister AS, Kriz V, Bryja V, Schambony A, Behrens J., 2011: Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).. J Biol Chem.: 286(22):19204-14.

2010

Cajanek L, Adlerz L, Bryja V, Arenas E., 2010: WNT unrelated activities in commercially available preparations of recombinant WNT3a.. J Cell Biochem.: 111(5):1077-9.

Foldynová-Trantírková S, Sekyrová P, Tmejová K, Brumovská E, Bernatík O, Blankenfeldt W, Krejcí P, Kozubík A, Dolezal T, Trantírek L, Bryja V., 2010: Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.. Breast Cancer Res.: 12(3):R30.

Book chapters

Vítězslav Bryja and Ondřej Bernatík, 2014: Dishevelled at the Crossroads of Pathways. In: eds. Steffan Hoppler & Randal T. Moon, Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions, Willey Publishers, pp. ISBN: 978-1-118-44416-0.

Patents

BRYJA, Vítězslav, Markéta KAUCKÁ, Karla PLEVOVÁ, Šárka PAVLOVÁ, Šárka POSPÍŠILOVÁ a Alois KOZUBÍK, 2016: Casein kinase 1 inhibitors for the treatment of B-cell chronic lymphocytic leukemia. . Patent CZ20120538 (A3), EP2882437 (B1).

PLEVOVÁ, Karla, Hana PLEŠINGEROVÁ, Antonín LIBRA, Zuzana JURČÍČKOVÁ, Jana KOTAŠKOVÁ, Šárka PAVLOVÁ, Vítězslav BRYJA, Šárka POSPÍŠILOVÁ and Alois KOZUBÍK, 2014: Sada pro stanovení prognózy chronické lymfocytární leukémie (Kit to determine prognosis of chronic lymphocytic leukemia). . Patent .

BRYJA, Vítězslav, Pavel KREJČÍ, Markéta KAUCKÁ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Alois KOZUBÍK, Jana KOTAŠKOVÁ and Karla PLEVOVÁ., 2012: Method of determination of diagnosis and prognosis in patients with B-cell chronic lymphocytic leukemia and oligonucleotides for use in this method. . Patent EP2462243 (A2).

Interview with Prof. Vitezslav Bryja at Mall.tv
Bryjalab at International Conference Analytical Cytometry 2019!
Interview with Vitezslav Bryja about developing CK1 inhibitors for treatment of chronic lymphocytic leukemia
Martin Zavřel has won the 1st place in biology category of SOC contest in South Moravian Region!
The dean´s award for our students! Congratulations!
Visit of Prof. Roel Nusse – the father of Wnt signaling field, in Bryjalab!
Masaryk University offers an exceptional start-up grant for outstanding scientists from abroad!