It has been known for many years that in temperate climates the European honey bee, Apis mellifera, exists in the form of two distinct populations within the year, short-living summer bees and long-living winter bees. However, there is only limited … Read More
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development, we employed gene trap knock-out … Read More
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL … Read More
Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhibit signaling through … Read More
Autoři: Eva Krkavcová, Jakub Kreisinger, Ludmila Hyánková, Pavel Hyršl, Veronika Javůrková Časopis: Open Biology ABSTRAKT Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is … Read More
Autoři: Barbora Šafránková, Martina Hermannová, Kristina Nešporová, Vladimír Velebný, and Lukáš Kubala Publikováno v: International Journal of Biological Macromolecules Abstrakt Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells … Read More
Michal KNAPP1, Pavel DOBEŠ2, Michal ŘEŘICHA1, Pavel HYRŠL2 1 Department of Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic; e-mails: knapp@fzp.czu.cz, rericham@fzp.czu.cz 2 Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty … Read More