WNT5B in Physiology and Disease

Abstract: WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often … Read More

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Welcoming new students in Bryjalab!

We cordially welcome new students in Bryjalab! Hope you will enjoy your first steps in the world of science! 🍀

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Dean´s Award for students of OFIŽ!

Our students succeeded with their research work and received the Dean’s Award! Congratulations to all and thank you for the great representation of the OFIŽ! 🍀👏   In the category of the best students of bachelor’s and master’s programs, the … Read More

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Congratulations to Dr. Paclíková! 🐾

Peťa Paclíková successfully completed her journey to a doctoral degree!

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Roles of individual human Dishevelled paralogs in the Wnt signalling pathways

Abstract: Dishevelled (DVL) proteins are key mediators of most Wnt pathways. In all vertebrates, three DVL paralogs are present (DVL1, DVL2 and DVL3) but it is poorly defined to what extent they are functionally redundant. Here, we generated T-REx HEK … Read More

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MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus

Abstract: The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development. Here, we … Read More

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Postdoc wanted! – Icahn School of Medicine at Mount Sinai, New York

The Sokol laboratory at the Icahn School of Medicine at Mount Sinai, New York, is looking for a motivated candidate to join their research group as a research fellow in the spring/summer of 2021. The laboratory studies how Wnt and … Read More

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A cellular and spatial map of the choroid plexus across brain ventricles and ages

Abstract: The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. Authors: Neil Dani … Read More

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Our work recently accepted in Development & highlighted in Development presents

Our article has been chosen by the Development editor Paola Arlotta (Harvard Stem Cell Institute) and selected for the monthly webinar “Development presents ….” ! The topic will be introduced by the first author Karol Kaiser, Ph.D.: „MEIS-WNT5A axis regulates … Read More

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Wnttalks: Talk by Bryjalab on Wnt5a and choroid plexus! – 6. 5. 2021

We cordially invite you to the Wnttalks, where our alumni Karol Kaiser, Ph.D. will present his research from Bryjalab that was focused on Wnt5 and choroid plexus in a talk: Meis1-Wnt5a axis – The story of two choroid plexuses. 6. … Read More

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Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling

Abstract: Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β. However, gaps exist in our understanding of how cilia formation and function is … Read More

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DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

Abstract: Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture … Read More

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Interview with V. Bryja: My personal scientific challenge is to understand how cells communicate at the molecular level

Faculty of Science MUNI has recently prepared an interview with Vita Bryja as a part of “Success Stories” series of scientists at the faculty.

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Phosphorylation-induced changes in the PDZ domain of Dishevelled 3

Abstract: The PDZ domain of Dishevelled 3 protein belongs to a highly abundant protein recognition motif which typically binds short C-terminal peptides. The affinity of the PDZ towards the peptides could be fine-tuned by a variety of post-translation modifications including … Read More

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CK1 inhibitors one step closer to patients – a new spin-off company CasInvent Pharma

A new spin-off company, CasInvent Pharma, a.s., has been established by Masaryk University (MU) in cooperation with its investment partner, i&i Prague, s.r.o. (Ltd), in order to facilitate further development of new compounds that could be used to treat certain … Read More

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Vitezslav Bryja and Pavlina Janovska awarded as MUNI Scientists

Selected scientists from Masaryk University were awarded for their outstanding research results and significant achievements in the field of research from 2019 to 2020 by the Vice-Rector for Research and Doctoral Studies prof. Šárka Pospíšilová. Later, they have managed to … Read More

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Targeting Casein Kinase 1 (CK1) in Hematological Cancers

The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. … Read More

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Congratulations to Dr. Radaszkiewicz!

Tomek Radaszkiewicz successfully completed his journey to a doctoral degree!

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Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

A comprehensive review on choroid plexus and its regulatory role in CNS by Karol Kaiser, Ph.D. just published in International Journal of Molecular Sciences! Follow us on Twitter. 😉

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Congratulations to Dr. Zankruti Dave!

Congratulations! On Tuesday, Zankruti successfully completed her journey to a doctoral degree! Her PhD defense took place online but we all managed it and enjoyed fruitful and stimulating discussion! We wish Zankruti the BEST OF LUCK with her postdoc position … Read More

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Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells

Another paper out and another step closer to a better understanding of #RNF43 tumor #suppressor action thanks to Tomek Radaszkiewicz!   Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells Cell Commun … Read More

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Dean´s Awards for students of OFIŽ!

Students of our department succeeded with their work and received the Dean’s Awards! Congratulations to all & thank you for the great representation of the department! In the category of the best students of bachelor’s and master’s programs: Mgr. Tomáš … Read More

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New preprint: Lyn controls chemotaxis and motility of CLL cells via phosphorylation of ROR1

ABSTRACT: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of the cell surface receptor ROR1. Both, BCR and ROR1 are therapeutic targets in … Read More

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The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled

Development 2020 147: dev186338 ABSTRACT: Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay … Read More

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New preprint: MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus

Just posted: MEIS-Wnt5a axis revealed as regulator of choroid plexus development ABSTRACT: The choroid plexus (ChP) produces cerebrospinal fluid and forms a critical barrier between the brain and the circulation. While the ChP forms in each brain ventricle, it adopts … Read More

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Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled

Cells 2020, 9(5), 1147. ABSTRACT: Wnt and BMP signaling pathways are two key molecular machineries regulating development and homeostasis. The efficient coordination of Wnt and BMP is essential in many developmental processes such as establishment of antero-posterior and dorso-ventral body … Read More

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CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells

PLoS One. 2020 Mar 25;15(3):e0229170. doi: 10.1371/journal.pone.0229170. ABSTRACT: Surface protein CD20 serves as the critical target of immunotherapy in various B-cell malignancies for decades, however its biological function and regulation remain largely elusive. Better understanding of CD20 function may help … Read More

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Thesis of Pavlína Janovská among the Top 13 in the Werner von Siemens competition!

PhD thesis of Mgr. Pavlína Janovská, Ph.D. was ranked among the 13 most successful dissertations in the Werner von Siemens 2019 competition! This year, 645 applications for diploma and doctoral theses entered the competition, so Pavlina’s placement is a truly … Read More

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Article by Míša Gregorová on the treatment of chronic lymphocytic leukemia in the Živa magazine

Our graduate Mgr. Michaela Gregorova has published an article in the new issue of Živa magazine, a popular scientific journal bringing contributions from biological disciplines. Míša published her article “The future in the treatment of chronic lymphocytic leukemia? Inhibition of … Read More

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Tomas Gybel´ won the prestigious Brno PhD Talent 2019 scholarship!

Mgr. Tomáš Gybel´, a doctoral student from the laboratory of prof. Vitezslav Bryja, won the prestigious Brno PhD Talent 2019 scholarship! Tomáš succeeded with his PhD project “Molecular and Functional Analysis of Casein Kinase 1 Biology”.  The scholarship is awarded … Read More

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Pavlina Janovska Among Top Noteworthy Women Scientists at MUNI!

Pavlina Janovska, Ph.D. has been chosen in the selection of noteworthy women scientists at MUNI on the occasion of The International Day of Women and Girls in Science (the 11th day of February) announced by United Nations. Congratulations! See the … Read More

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OFIŽ students received grants in the Rector Program to support their research projects!

Students of our department have succeeded in the grant competition of the Rector Program!Grants are awarded to outstanding students of Master’s degree programs for research related to their thesis.Congratulations!   The following students received support for their projects: Bc. Eliška … Read More

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Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.

Cell Communication and Signaling volume 17, Article number: 170 (2019) BACKGROUND: Dishevelled (DVL) is an essential component of the Wnt signaling cascades. The function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose … Read More

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WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer

Theranostics 2020; 10(2):537-552. doi:10.7150/thno.37423 High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is the deadliest gynecological disease which results in a five-year survival rate of 30% or less. HGSC is characterized by the early and rapid development … Read More

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Congratulations to Peťa & Tomek!

Peťa and Tomek successfully passed their doctoral state exams! Congratulations!

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Interview with Prof. Vitezslav Bryja for Mall.tv

Have a look at the interview with prof. Vítězslav Bryja for the Neuron Fund for Support of Science, which explains prof. Bryja´s research in a clear and very nice way. The interview was created as a part of „Scientists under … Read More

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Bryjalab at International Conference Analytical Cytometry 2019!

Our group presenting the latest research results at the International Conference Analytical Cytometry 2019 organized by Czech Society for Analytical Cytometry. Great to hear exciting news from the field of flowcytometry!

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OpenDay & PhD Day 2019!

At the beginning of the semester, we introduced our department to students who are interested in studying at Faculty of Science at Masaryk University. If you couldn’t visit us, don’t worry! Information materials are available online – students looking for … Read More

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Interview with Vitezslav Bryja about developing CK1 inhibitors for treatment of chronic lymphocytic leukemia

Masaryk University Technology Transfer Office prepared an interview with Vitezslav Bryja about developing inhibitors of casein kinase 1 in collaboration with Kamil Paruch´s group (Department of Chemistry) that can be used in the future as treatment of chronic lymphocytic leukemia … Read More

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The Dean´s award for our students! Congratulations!

Students of our dept. received the Dean´s award for their high-level theses & publication successes! Good job! We wish you a lot of success in your further research!   Awards for outstanding diploma thesis: Michaela Gregorová: Novel casein kinase 1 … Read More

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Martin Zavřel has won the 1st place in biology category of SOC contest in South Moravian Region!

Congratulations! High school student in our laboratory, Martin Zavřel has recently won the 1st place in biology category of Students´ Professional Activities national contest (SOČ) in the South Moravian Region! He succeeded with his work “WNT signaling in the pathogenesis of chronic lymphocytic leukemia” supervised … Read More

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Visit of Prof. Roel Nusse – the father of Wnt signaling field, in Bryjalab!

Exciting day! Prof. Roel Nusse from Stanford University Medical Center & Howard Hughes Medical Institute, the father of Wnt signaling field, visited Bryjalab today and gave a Mendel lecture within the MU Life Sciences seminar: https://mendellectures.muni.cz/#_lect_back9. Thanks for your visit and great discussion!

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Short interview with Karol Kaiser in “Hospodarske noviny” newspapers!

One of the main Czech newspapers – „Hospodarske noviny“ reported about Karol Kaiser´s research of long-range transport of biologically active Wnt5A via lipoprotein particles in the cerebrospinal fluid (http://bit.ly/2PYkeK2)! Don´t get confused by a bit misleading title of the interview.  https://archiv.ihned.cz/c1-66573160-bunky-dokazou-rakovinu-po-tele-posilat-na-dalku-zjistili-vedci-z-masarykovy-univerzity-jejich-objev-muze-zlepsit-lecbu-nemoci

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Pavlina Janovska received rector´s award for outstanding scientists!

Congratulations! Pavlina Janovska, Ph.D. received the rector´s award for outstanding scientists under age of 35 at Masaryk University! Pavlina´s research is focused on CK1 inhibitors and treatment of chronic lymphocytic leukemia, see her publication list here: http://bit.ly/2JmGtc2! See video from … Read More

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Magazine M reports about publication successes of Bryjalab!

Magazine M of Masaryk University reports about 2 publication successes of Bryjalab in Nature Communications!: “Buňky spolu komunikují na větší vzdálenost, než se předpokládalo!” A story about long-range transport of Wnt5A by Karol Kaiser which is an exciting novel view … Read More

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Anna Kotrbova presenting MS analysis of extracellular vesicles at ISEV 2019!

Bryjalab continues in the development of methods for the analysis of exosomes: After flow cytometry optimization https://doi.org/10.3402/jev.v4.25530 … & TEM Exosome Analyzer https://doi.org/10.1080/20013078.2018.1560808 … published in Journal of Extracellular Vesicles now presents EV isolation method comparison using proteomic data! Anicka Kotrbova presented her poster Mass spectrometry analysis of  small extracellular … Read More

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Interview with Kacka Kudlickova in Magazine M

Interview with our student Kacka Kudlickova about her work in the lab already during her high school studies, lecturing in Bioskop center (bioskop.muni.cz) and organizing a conference for young people: Ceske-nadeje.cz “Středoškolák v laboratoři není sci-fi!”

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Casein kinase 1 inhibitors presented at BioEuropeSpring 2019

Vita Bryja presented the casein kinase 1 inhibitors that are being developed in our laboratory together with Kamil Paruch´s team at the international partnering conference BIOEuropeSpring 2019 in Vienna! Fingers crossed for the future cooperations!

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Great success of Kacka Kudlickova in international contest BYSCC in China!

Congratulations! Our student Kacka Kudlickova won the shared 1st place in the international contest Beijing Youth Science Creation Competition (BYSCC) in China! Kacka presented her work “Mysterious proteins from RNFT family in intercellular signaling and tumors”.

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Visit of One of the Key Inventors of Crispr–Cas9 Technology – Prof. Emmanuelle Charpentier

Today, it is Vita Bryja´s honor to host one of the key inventors of the CRISPR–Cas9 technology – Prof. Emmanuelle Charpentier (Max Planck Unit for the Science of Pathogens, Germany), who is visiting our lab and giving a Mendel lecture “CRISPR-Cas9: a … Read More

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PF 2019!

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Congratulations to Kacka Kudlickova!

Congratulations to our student Kacka Kudlickova! Thanks to Kacka´s great success in Healthcare category of Students´ Professional Activities national contest (SOČ) where she won the 2nd place, now she has been chosen to represent the Czech Republic in the international contest Beijing … Read More

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Congratulations to Dr. Harnoš!

We cordially congratulate to Jakub Harnoš, Ph.D. who has successfully completed his journey to a doctoral degree!And we wish him the BEST OF LUCK in his new postdoc position in New York in Sergei Sokol´s laboratory!

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Visit of Prof. Rudolf Jaenisch

Last week, Masaryk University had the honor to host Prof. Rudolf Jaenisch, who created the first transgenic animal model in history (see Prof. Jaenisch´s biography here). Prof. Rudolf Jaenisch also visited our lab and gave a lecture “Epigenetic Regulation in Development, Aging and … Read More

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Visit of Prof. Eric F. Wieschaus – Nobel Laureate in the Field of Physiology

Last week, Masaryk University had the honor to host the Nobel Prize laureate, Prof. Eric F. Wieschaus, who was awarded the Nobel Prize (1995) in the field of Physiology with Edward B. Lewis and Christiane Nüsslein-Volhard as co-recipients, for their work revealing … Read More

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Pavlina Janovska Won the 3rd Place in Sanofi Competition!

Congratulations to Pavlína Janovská who won the 3rd place in competition SANOFI PRIZE FOR PHARMACY 2018 whose purpose is to award the best PhD research works in experimental biomedical and pharmaceutical research! Pavlina´s great success was noticed by several media: ibrno.cz denik.cz … Read More

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Congratulations to Kristína & Our New Bachelors!

Congratulations to Kristína Gömöryová who successfully obtained a Master’s degree and was admitted to PhD study! And congratulations also to our new bachelors who smoothly defended their theses! Miroslav Micka, Nikodém Zezula, Štěpán Čada, Jana Lapinová, Petra Kompaníková

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Kacka Kudlickova Won the 2nd Place in SOC!

Congratulations to our student Kacka Kudlickova! She won the second place in Healthcare category of Students´ Professional Activities national contest (SOC – Středoškolská odborná činnost)!

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Professor Appointment Lecture by Vita Bryja

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Vita Bryja in Universitas Magazine

Two articles – about czech science and career in science and family life (with contribution of Vita Bryja), were published in Universitas magazine (in czech only): Universitas: Anketa: Co je na české vědě špatně? A jak tu udržet mladé? Universitas: … Read More

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Bryjalab Team Building!

We are more than happy that we helped our boss to dig manually the greatest hole in the world #CestaDoStreduZeme #VybagrujteCechy,SlovenskoChceMore #ZerykInLove

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