A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response

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The inhalation of metal (including lead) nanoparticles poses a real health issue to people and animals living in polluted and/or industrial areas. In this study, we exposed mice to lead(II) nitrate nanoparticles [Pb(NO3)2 NPs], which represent a highly soluble form … Read More

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

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Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders often affecting skeletal development. This includes Jeune syndrome or asphyxiating thoracic dystrophy (ATD), an autosomal recessive skeletal disorder. Unraveling the responsible molecular pathology helps illuminate mechanisms responsible … Read More

Získali jsme akreditaci pro chov a experimentální využití rybiček a žab 🐟🐸

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Docentka Marcela Buchtová spolu s Lenkou Doubkovou, Nikodémem Zezulou a Pavlem Dobešem úspěšně dobojovali s náročným akreditačním procesem a nekonečnými lejstry a OFIŽ tak získalo povolení od Ministerstva zemědělství pro chov a experimentální využití rybiček, žab a dalších živočichů – především jde o druhy Danio rerio a Xenopus laevis. Posune … Read More

Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon

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Secondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary … Read More

The effects of nano-sized PbO on biomarkers of membrane disruption and DNA damage in a sub-chronic inhalation study on mice

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Although the production of engineered nanoparticles increases our knowledge of toxicity and mechanisms of bioactivity during relevant exposures is lacking. In the present study, mice were exposed to PbO nanoparticles (PbONP; 192.5 µg/m3; 1.93 × 106 particles/cm3) for 2, 5 and 13 weeks through … Read More

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