Recent developments in the elucidation of regulation of gene expression opened a whole spectrum of new-born and revived mechanisms of tuning and switching the gene expression in norm and in pathology, such as RNA interference, chromatin remodeling and other epigenetic phenomena. Due to swift development of new sequencing techniques during last years a large volume of genomic sequences became available, with concomitant bioinformatic analyses. Accumulating knowledge in "classical" molecular and cell biology has to be linked to the modern genomics, for the mutual benefit, towards a comprehensive picture of modern biology. The workshop is aimed at outlining strategic trends of research that would combine the first hand experience in various front line genome studies, by the topmost experts in the genomic disciplines.