Publications

2025

Almeida J, Resende DISP, Silva R, Villasante A, Murphy C, Zingales V, Palmeira A, Škoda J, Broso F, Vadivellu A, Oliveira P, Reis S, Nunes C, Loh AHP, Ferreira JM, Martins EP, Costa BM, Inga A, Samitier J, Sousa E, Saraiva L.
Improving neuroblastoma therapy with a new p53 family-activating agent.
European Journal of Pharmacology, 2025;178295.

Knechtova V, Mahdal M, Staniczkova Zambo I, Skoda J, Neradil J*.
Biomarkers and therapeutic targets in giant cell tumor of bone: A comprehensive review.
Bone. 2025;199:117566.

Cagalinec M, Mohd A, Borecka S, Bultynck G, Choubey V, Yanovsky-Dagan S, Ezer S, Gasperikova D, Harel T, Jurkovicova D, Kaasik A, Liévens JC, Maurice T, Peviani M, Richard EM, Skoda J, Skopkova M, Tarot P, Van Gorp R, Zvejniece L, Delprat B.
Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer.
Biochim Biophys Acta Mol Cell Res. 2025;1872(5):119954.

Leck LYW, Abd El-Aziz YS, McKelvey KJ, Park KC, Sahni S, Lane DJR, Skoda J*, Jansson PJ*.
Cancer stem cells: Masters of all traits.
BBA-Mol Basis Dis. 2025;1871(3):167549.

Mayr L, Neyazi S, Schwark K, Trissal M, Beck A, Labelle J, Eder SK, Weiler-Wichtl L, Marques JG, de Biagi-Junior CAO, Lo Cascio C, Chapman O, Sridhar S, Kenkre R, Dutta A, Wang S, Wang J, Hack O, Nascimento A, Nguyen CM, Castellani S, Rozowsky JS, Groves A, Panditharatna E, Cruzeiro GAV, Haase RD, Tabatabai K, Madlener S, Wadden J, Adam T, Kong S, Miclea M, Patel T, Bruckner K, Senfter D, Lämmerer A, Supko J, Guntner AS, Palova H, Neradil J, Stepien N, Lötsch-Gojo D, Berger W, Leiss U, Rosenmayr V, Dorfer C, Dieckmann K, Peyrl A, Azizi AA, Baumgartner A, Slaby O, Pokorna P, Clark LM, Cameron A, Nguyen QD, Wakimoto H, Dubois F, Greenwald NF, Bandopadhayay P, Beroukhim R, Ligon K, Kramm C, Bronsema A, Bailey S, Stucklin AG, Mueller S, Skrypek M, Martinez N, Bowers DC, Jones DTW, Jones C, Jäger N, Sterba J, Müllauer L, Haberler C, Kumar-Sinha C, Chinnaiyan A, Mody R, Chavez L, Furtner J, Koschmann C, Gojo J, Filbin MG.
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
Cancer Cell. 2025;43(4):740-756.e8

Tinka P, Pokorná P, Kýr M, Pavelka Z, Vejmělková K, Pálová H, Neradil J, Ježová M, Slabý O, Štěrba J.
Individualized therapeutic approaches for relapsed and refractory pediatric ependymomas: a single institution experience
J Neurooncol.  2025;173(2):479-488

2024

Pleskač P, Fargeas CA, Veselska R, Corbeil D*, Skoda J*.
Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease.
Cell Mol Biol Lett. 2024; 29(1):41. 

Borankova K, Solny M, Krchniakova M, Skoda J*.
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance.
Life Sci Alliance. 2024;8(2):e202402870. 

Curylova L, Staniczkova Zambo I, Neradil J, Kyr M, Jurackova N, Pavlova S, Polaskova K, Mudry P, Sterba J, Veselska R, Skoda J*.
Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits.
Cell Oncol. 2024;47(6):2317-2334.

Apostolopoulos V, Boháč P, Marcián P, Staniczková Zambo I, Pazourek L, Mahdal M, Neradil J, Návrat T, Tomáš T*.
ASO Author Reflections: The Effect of Local Adjuvants on Cortical Bone Following Intralesional Curettage of Bone Tumors
Ann Surg Oncol. 2024;31(9):6333-6334. 

Apostolopoulos V, Boháč P, Marcián P, Staniczková Zambo I, Pazourek L, Mahdal M, Neradil J, Návrat T, Tomáš T*.
Micro-CT, Mechanical, and Histological Examination of the Effect of Local Adjuvants on Porcine Cortical Bone Following Intralesional Curettage of Bone Tumors
Ann Surg Oncol. 2024;31(9):6282-6290.

2023

Borankova K, Krchniakova M, Leck LYW, Kubistova A, Neradil J, Jansson PJ, Hogarty MD, Skoda J*.
Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma.
Cell Death Dis. 2023;14(11):747

2022

Almeida J, Mota I, Skoda J, Sousa E, Cidade H, Saraiva L*
Deciphering the Role of p53 and TAp73 in Neuroblastoma: From Pathogenesis to Treatment
Cancers 2022;14(24), 6212

Kameneva P, Melnikova V I, Kastriti M E, Kurtova A, Kryukov E, Murtazina A, Faure L, Poverennaya I, Artemov A V, Kalinina T S, Kudryashov N V, Bader M, Skoda J, Chlapek P, Curylova L, Sourada L, Neradil J, Tesarova M, Pasqualetti M, Gaspar P, Yakushov V D, Sheftel B I, Zikmund T, Kaiser J, Fried K, Alenina N, Voronezhskaya E E*, Adameyko I*
Serotonin limits generation of chromaffin cells during adrenal organ development
Nat Commun 2022;13(1), 2901

Çoku J, Booth D M, Skoda J, Pedrotty M C, Vogel J, Liu K, Vu A, Carpenter E L, Ye J C, Chen M A, Dunbar P, Scadden E, Yun T D, Nakamaru-Ogiso E, Area-Gomez E, Li Y, Goldsmith K C, Reynolds C P, Hajnoczky G, Hogarty M D*
Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance
EMBO J 2022;41(8):e108272

Curylova L, Ramos H, Saraiva L*, Skoda J*
Noncanonical roles of p53 in cancer stemness and their implications in sarcomas
Cancer Lett 2022;525:131-145

Macsek P*, Skoda J*, Krchniakova M*, Neradil J*, Veselska R*
Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma.
Int J Mol Sci. 2022; 23(1):376.

2021

Seebacher N A, Krchniakova M, Stacy A E, Skoda J*, Jansson P J*
Tumour Microenvironment Stress Promotes the Development of Drug Resistance
Antioxidants (Basel) 2021;10(11):1801

Mahdal M, Neradil J, Mudry P, Paukovcekova S, Staniczkova Zambo I, Urban J, Macsek P, Pazourek L, Tomas T,  Veselska R*
New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling
Cancers (Basel).202;13(14):3543.

2020

Paukovcekova S, Skoda J, Neradil J, Mikulenkova E, Chlapek P, Sterba J, Richardson D R, Veselska R*
Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms
Cancers 2020,12(12):3781

Mikulenkova E, Neradil J, Vymazal O, Skoda J*, Veselska R
NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation
Cells 2020;9(3):692

Gojo J, Pavelka Z, Zapletalova D, Schmook M T, Mayr L, Madlener S, Kyr M, Vejmelkova K, Smrcka M, Czech T, Dorfer C, Skotakova J, Azizi A A, Chocholous M, Reisinger D, Lastovicka D, Valik D, Haberler C, Peyrl A, Noskova H, Pál K, Jezova M, Veselska R, Kozakova S, Slaby O, Slavc I, Sterba J*
Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities
Frontiers in Oncology 2020;9:1436

Polaskova K*, Merta T, Martincekova A, Zapletalova D, Kyr M, Mazanek P, Krenova Z, Mudry P, Jezova M, Tuma J, Skotakova J, Cervinkova I, Valik D, Zdrazilova-Dubska L, Noskova H, Pal K, Slaby O, Fabian P, Kozakova S, Neradil J, Veselska R, Kanderova V, Hrusak O, Freiberger T, Klement G L, Sterba J
Comprehensive Molecular Profiling for Relapsed/Refractory Pediatric Burkitt Lymphomas—Retrospective Analysis of Three Real-Life Clinical Cases—Addressing Issues on Randomization and Customization at the Bedside
Frontiers in Oncology 2020;9:1531

Krchniakova M, Skoda J, Neradil J, Chlapek P, Veselska R
Repurposing tyrosine kinase inhibitors to overcome multidrug resistance in cancer: A focus on transporters and lysosomal sequestration
International Journal of Molecular Sciences 2020;21(9):315

Skoda J*, Neradil J, Zambo I S, Nunukova A, Macsek P, Borankova K, Dobrotkova V, Nemec P, Sterba J, Veselska R*
Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells
Cancers 2020;12(1):196

2019

Skoda J, Borankova K, Jansson P J, Huang M L, Veselska R, Richardson D R*
Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
Pharmacol Res 2019;139:298-313

Neradil J, Kyr M, Polaskova K, Kren L, Macigova P, Skoda J, Sterba J, Veselska R*
Phospho-Protein Arrays as Effective Tools for Screening Possible Targets for Kinase Inhibitors and Their Use in Precision Pediatric Oncology
Front Oncol 2019;9:930 

Kyr M*, Polaskova K, Kuttnerova Z, Merta T, Neradil J, Berkovcova J, Horky O, Jezova M, Veselska R, Klement G L, Valik D, Sterba J
Individualization of Treatment Improves the Survival of Children With High-Risk Solid Tumors: Comparative Patient Series Analysis in a Real-Life Scenario
Front Oncol 2019;9:644

Gomes S, Raimundo L, Soares J, Loureiro J B, Leao M, Ramos H, Monteiro M N, Lemos A, Moreira J, Pinto M, Chlapek P, Veselska R, Sousa E*, Saraiva L*
New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma
Cancer Lett 2019;446:90-102 

Dobrotkova V, Chlapek P, Jezova M, Adamkova K, Mazanek P, Sterba J, Veselska R*
Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers
PLoS One 2019;14(6):e0218269 

2018

Sramek M, Neradil J, Macigova P, Mudry P, Polaskova K, Slaby O, Noskova H, Sterba J, Veselska R*
Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis
Int J Mol Sci 2018;19(9):2599

Skoda J*, Veselska R
Cancer stem cells in sarcomas: Getting to the stemness core
Biochim Biophys Acta Gen Subj 2018;1862(10):2134-2139

Chlapek P, Slavikova V, Mazanek P, Sterba J, Veselska R*
Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids
Int J Mol Sci 2018;19(1):132

2017

Sramek M, Neradil J, Veselska R
Much more than you expected: The non-DHFR-mediated effects of methotrexate
Biochim Biophys Acta Gen Subj 2017;1861(3):499-503

Mudry P*, Slaby O, Neradil J, Soukalova J, Melicharkova K, Rohleder O, Jezova M, Seehofnerova A, Michu E, Veselska R, Sterba J
Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene
BMC Cancer 2017:17(1):119

Chlapek P, Zitterbart K, Kren L, Filipova L, Sterba J, Veselska R*
Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups
PLoS One 2017;12(2):e0172552

2016

Skoda J, Nunukova A, Loja T, Zambo I, Neradil J, Mudry P, Zitterbart K, Hermanova M, Hampl A, Sterba J, Veselska R*
Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice
Tumor biology 2016;37(7):9535-9548 

Skoda J, Hermanova M, Loja T, Nemec P, Neradil J, Karasek P, Veselska R*
Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma
PLOS ONE 2016;11(7):e0159255

Zambo I, Hermanova M, Zapletalova D, Skoda J, Mudry P, Kyr M, Zitterbart K, Sterba J, Veselska R*
Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas
Cancer Biomarkers 17(1), 107-116 (2016).

2015

Mikulenkova E, Neradil J, Zitterbart K, Sterba J, Veselska R*
Overexpression of the Delta Np73 isoform is associated with centrosome amplification in brain tumor cell lines
Tumor Biology 2015;36(10):7483-7491

Nunukova A, Neradil J, Skoda J, Jaros J, Hampl A, Sterba J, Veselska R*
Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines
International Journal of Molecular Medicine 2015; 36(1):65-72

Neradil J, Veselska R
Nestin as a marker of cancer stem cells
Cancer Science 2015;106(7):803-811

2014

Krzyzankova M, Chovanova S, Chlapek P, Radsetoulal M, Neradil J, Zitterbart K, Sterba J, Veselska R*
LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines
Tumor Biology 2014;35(8):7617-7627

Chlapek P, Neradil J, Redova M, Zitterbart K, Sterba J, Veselska R*
The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression
Cancer Cell International 2014;13:14:51

Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R*
EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy
Oncology Reports 2014;31(1):480-487

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