Publikace

2022

Almeida J, Mota I, Skoda J, Sousa E, Cidade H, Saraiva L

Deciphering the Role of p53 and TAp73 in Neuroblastoma: From Pathogenesis to Treatment Journal Article

Cancers 14(24), 6212 (2022).

Paukovcekova S, Krchniakova M, Chlapek P, Neradil J, Skoda J, Veselska R

Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors Journal Article

Int J Mol Sci 23(15) (2022).

Kameneva P, Melnikova V I, Kastriti M E, Kurtova A, Kryukov E, Murtazina A, Faure L, Poverennaya I, Artemov A V, Kalinina T S, Kudryashov N V, Bader M, Skoda J, Chlapek P, Curylova L, Sourada L, Neradil J, Tesarova M, Pasqualetti M, Gaspar P, Yakushov V D, Sheftel B I, Zikmund T, Kaiser J, Fried K, Alenina N, Voronezhskaya E E, Adameyko I

Serotonin limits generation of chromaffin cells during adrenal organ development Journal Article

Nat Commun 13(1), 2901 (2022).

Çoku J, Booth D M, Skoda J, Pedrotty M C, Vogel J, Liu K, Vu A, Carpenter E L, Ye J C, Chen M A, Dunbar P, Scadden E, Yun T D, Nakamaru-Ogiso E, Area-Gomez E, Li Y, Goldsmith K C, Reynolds C P, Hajnoczky G, Hogarty M D

Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance Journal Article

EMBO J 41(8), e108272 (2022).

Curylova L, Ramos H, Saraiva L, Skoda J

Noncanonical roles of p53 in cancer stemness and their implications in sarcomas Journal Article

Cancer Lett 525, 131–145 (2022).

Krchniakova M, Paukovcekova S, Chlapek P, Neradil J, Skoda J, Veselska R

Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells Journal Article

Front Pharmacol 13, 976955 (2022).

2021

Macsek P, Skoda J, Krchniakova M, Neradil J, Veselska R

Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma Journal Article

Int J Mol Sci 23(1) (2021).

Seebacher N A, Krchniakova M, Stacy A E, Skoda J, Jansson P J

Tumour Microenvironment Stress Promotes the Development of Drug Resistance Journal Article

Antioxidants (Basel) 10(11) (2021).

2020

Paukovcekova S, Skoda J, Neradil J, Mikulenkova E, Chlapek P, Sterba J, Richardson D R, Veselska R

Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms Journal Article

Cancers 12(12), 3781 (2020).

Mikulenkova E, Neradil J, Vymazal O, Skoda J, Veselska R

NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation Journal Article

Cells 9(3), 692 (2020).

Skoda J, Neradil J, Zambo I S, Nunukova A, Macsek P, Borankova K, Dobrotkova V, Nemec P, Sterba J, Veselska R

Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells Journal Article

Cancers 12(1), 196 (2020).

Krchniakova M, Skoda J, Neradil J, Chlapek P, Veselska R

Repurposing tyrosine kinase inhibitors to overcome multidrug resistance in cancer: A focus on transporters and lysosomal sequestration Journal Article

International Journal of Molecular Sciences 21(9) (2020).

Polaskova K, Merta T, Martincekova A, Zapletalova D, Kyr M, Mazanek P, Krenova Z, Mudry P, Jezova M, Tuma J, Skotakova J, Cervinkova I, Valik D, Zdrazilova-Dubska L, Noskova H, Pal K, Slaby O, Fabian P, Kozakova S, Neradil J, Veselska R, Kanderova V, Hrusak O, Freiberger T, Klement G L, Sterba J

Comprehensive Molecular Profiling for Relapsed/Refractory Pediatric Burkitt Lymphomas—Retrospective Analysis of Three Real-Life Clinical Cases—Addressing Issues on Randomization and Customization at the Bedside Journal Article

Frontiers in Oncology 9 (2020).

Gojo J, Pavelka Z, Zapletalova D, Schmook M T, Mayr L, Madlener S, Kyr M, Vejmelkova K, Smrcka M, Czech T, Dorfer C, Skotakova J, Azizi A A, Chocholous M, Reisinger D, Lastovicka D, Valik D, Haberler C, Peyrl A, Noskova H, Pál K, Jezova M, Veselska R, Kozakova S, Slaby O, Slavc I, Sterba J

Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities Journal Article

Frontiers in Oncology 9 (2020).

2019

Dobrotkova V, Chlapek P, Jezova M, Adamkova K, Mazanek P, Sterba J, Veselska R

Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers Journal Article

PLoS One 14(6), e0218269 (2019).

Gomes S, Raimundo L, Soares J, Loureiro J B, Leao M, Ramos H, Monteiro M N, Lemos A, Moreira J, Pinto M, Chlapek P, Veselska R, Sousa E, Saraiva L

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma Journal Article

Cancer Lett 446, 90-102 (2019).

Kyr M, Polaskova K, Kuttnerova Z, Merta T, Neradil J, Berkovcova J, Horky O, Jezova M, Veselska R, Klement G L, Valik D, Sterba J

Individualization of Treatment Improves the Survival of Children With High-Risk Solid Tumors: Comparative Patient Series Analysis in a Real-Life Scenario Journal Article

Front Oncol 9, 644 (2019).

Neradil J, Kyr M, Polaskova K, Kren L, Macigova P, Skoda J, Sterba J, Veselska R

Phospho-Protein Arrays as Effective Tools for Screening Possible Targets for Kinase Inhibitors and Their Use in Precision Pediatric Oncology Journal Article

Front Oncol 9, 930 (2019).

Skoda J, Borankova K, Jansson P J, Huang M L, Veselska R, Richardson D R

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies Journal Article

Pharmacol Res 139, 298-313 (2019).

Veselska R, Jezova M, Kyr M, Mazanek P, Chlapek P, Dobrotkova V, Sterba J

Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy Journal Article

Front Oncol 9, 1221 (2019).

2018

Dobrotkova V, Chlapek P, Mazanek P, Sterba J, Veselska R

Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy Journal Article

BMC Cancer 18(1), 1059 (2018).

Chlapek P, Slavikova V, Mazanek P, Sterba J, Veselska R

Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids Journal Article

Int J Mol Sci 19(1) (2018).

Skoda J, Veselska R

Cancer stem cells in sarcomas: Getting to the stemness core Journal Article

Biochim Biophys Acta Gen Subj 1862(10), 2134-2139 (2018).

Sramek M, Neradil J, Macigova P, Mudry P, Polaskova K, Slaby O, Noskova H, Sterba J, Veselska R

Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis Journal Article

Int J Mol Sci 19(9) (2018).

2017

Chlapek P, Zitterbart K, Kren L, Filipova L, Sterba J, Veselska R

Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups Journal Article

PLoS One 12(2), e0172552 (2017).

Mudry P, Slaby O, Neradil J, Soukalova J, Melicharkova K, Rohleder O, Jezova M, Seehofnerova A, Michu E, Veselska R, Sterba J

Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene Journal Article

BMC Cancer 17(1), 119 (2017).

Sramek M, Neradil J, Veselska R

Much more than you expected: The non-DHFR-mediated effects of methotrexate Journal Article

Biochim Biophys Acta Gen Subj 1861(3), 499-503 (2017).

2016

Skoda J, Hermanova M, Loja T, Nemec P, Neradil J, Karasek P, Veselska R

Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma Journal Article

PLOS ONE 11(7) (2016).

Skoda J, Nunukova A, Loja T, Zambo I, Neradil J, Mudry P, Zitterbart K, Hermanova M, Hampl A, Sterba J, Veselska R

Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice Journal Article

TUMOR BIOLOGY 37(7), 9535-9548 (2016).

Sramek M, Neradil J, Sterba J, Veselska R

Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation Journal Article

CANCER CELL INTERNATIONAL 16 (2016).

Chlapek P, Slavikova V, Sterba J, Veselska R

Sensitivity to the natural and synthetic retinoids in relation to the expression of selected protein markers in neuroblastoma cell lines Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 38(1), S55 (2016).

Neradil J, Melicharkova K, Mudry P, Veselska R, Sterba J

Detailed analysis of phosphorylated receptor tyrosine kinases and downstream signaling pathways in selected pediatric malignancies Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 38(1), S55 (2016).

Veselska R, Nunukova A, Skoda J, Loja T, Zambo I, Neradil J, Hermanova M, Hampl A, Sterba J

Tumorigenicity and expression of the core stem cell markers in rhabdomyosarcoma cells Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 38(1), S54 (2016).

Zambo I, Hermanova M, Zapletalova D, Skoda J, Mudry P, Kyr M, Zitterbart K, Sterba J, Veselska R

Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas Journal Article

CANCER BIOMARKERS 17(1), 107-116 (2016).

2015

Neradil J, Sramek M, Mrkvicova M, Zitterbart K, Sterba J, Veselska R

METHOTREXATE AND ALL-TRANS RETINOIC ACID COMBINED TREATMENT FOR INDUCTION OF OSTEOSARCOMA CELL LINES DIFFERENTIATION IN VITRO Journal Article

PEDIATRIC BLOOD & CANCER 62(4), S268 (2015).

Skoda J, Neradil J, Zambo I, Hermanova M, Sterba J, Veselska R

IDENTIFICATION OF CANCER STEM CELLS IN OSTEOSARCOMA CELL LINES: CHARACTERIZATION OF CANCER STEM CELL MARKERS EXPRESSION AND IN VIVO TUMORIGENICITY Journal Article

PEDIATRIC BLOOD & CANCER 62(4), S269 (2015).

Sramek M, Neradil J, Mrkvicova M, Zitterbart K, Sterba J, Veselska R

METHOTREXATE INDUCES EPIGENETIC ALTERATIONS IN OSTEOSARCOMA CELL LINES Journal Article

PEDIATRIC BLOOD & CANCER 62(4), S269 (2015).

Mikulenkova E, Neradil J, Zitterbart K, Sterba J, Veselska R

Overexpression of the Delta Np73 isoform is associated with centrosome amplification in brain tumor cell lines Journal Article

TUMOR BIOLOGY 36(10), 7483-7491 (2015).

Neradil J, Veselska R

Nestin as a marker of cancer stem cells Journal Article

CANCER SCIENCE 106(7), 803-811 (2015).

Nunukova A, Neradil J, Skoda J, Jaros J, Hampl A, Sterba J, Veselska R

Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 36(1), 65-72 (2015).

Neradil J, Pavlasova G, Sramek M, Kyr M, Veselska R, Sterba J

DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: The same outcome of treatment with different doses in sensitive cell lines Journal Article

ONCOLOGY REPORTS 33(5), 2169-2175 (2015).

Veselska R, Skoda J, Nunukova A, Loja T, Zambo I, Neradil J, Hermanova M, Mudry P, Zitterbart K, Zapletalove D, Kyr M, Jaros J, Hamp A, Sterba J

Cancer stem cell markers in pediatric sarcomas: Comparative analysis of their expression in tumor tissues and derived cell lines Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 36(1), S71 (2015).

2014

Krzyzankova M, Chovanova S, Chlapek P, Radsetoulal M, Neradil J, Zitterbart K, Sterba J, Veselska R

LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines Journal Article

TUMOR BIOLOGY 35(8), 7617-7627 (2014).

Chlapek P, Neradil J, Redova M, Zitterbart K, Sterba J, Veselska R

The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression Journal Article

CANCER CELL INTERNATIONAL 14 (2014).

Neradil J, Veselska R, Mudry P, Melicharkova K, Sterba J

Mapping of receptor tyrosine kinases activation and downstream signaling in rhabdomyosarcoma Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34(1), S78 (2014).

Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R

EGFR signaling in glioblastoma cells with a loss of EGFR gene copy and unusually mild clinical course of disease Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34(1), S78 (2014).

Sramek M, Neradil J, Mrkvicova M, Zitterbart K, Sterba J, Veselska R

Methotrexate-dependent changes of DNA methylation and gene expression in osteosarcoma cell lines Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34(1), S79 (2014).

Veselska R, Nunukova A, Skoda J, Neradil J, Jaros J, Hermanova M, Zambo I, Mudry P, Zitterbart K, Hampl A, Sterba J

Nuclear localization of CD133 in sarcoma cells Journal Article

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34(1), S81 (2014).

Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R

EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy Journal Article

ONCOLOGY REPORTS 31(1), 480-487 (2014).

2013

Veselska R, Neradil J, Nekulova M, Dobrucka L, Vojtesek B, Sterba J, Zitterbart K

Intracellular distribution of the Delta Np73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies Journal Article

HISTOLOGY AND HISTOPATHOLOGY 28(7), 913-924 (2013).