Laboratory of Cell Differentiation

The laboratory was established in 1994 to investigate principles of proliferation, differentiation, migration and programmed cell death of cancer cells. As a model we use cancer cell lines of various origin (breast, colon, lung, leukemia etc). Using multiple techniques of molecular and cellular biology, we investigate function of specific genes and the role of tumor microenvironment in these processes. We are also interested in testing the tumor suppressing effects of various anti-cancer drugs. The aim of our work is to perfom the basic experiments in tissue cultures, confirm their results in laboratory mice and to participate in clinical studies to provide benefits to cancer patients.

Latest news

Postdoc/Research Assistant - Open Position

30th January 2018

We are seeking a motivated scientist for projects-funded position in our laboratory. For more details see or ask directly at .

New paper in Oncogene !!!!!

19th September 2017

Paper by Lucka Knopfová, et al. entitledTranscription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding“ has just been accepted for publication in Oncogene. Congratulation to Lucka and all co-authors.


Wedding no. 2

1st September 2017

Sára Kučeráková has just said YES to Peter Lenárt in August, 18th. Congratulations and good luck.