Laboratory of Cell Differentiation
The laboratory was established in 1994 to investigate principles of proliferation, differentiation, migration and programmed cell death of cancer cells. As a model we use cancer cell lines of various origin (breast, colon, lung, leukemia etc). Using multiple techniques of molecular and cellular biology, we investigate function of specific genes and the role of tumor microenvironment in these processes. We are also interested in testing the tumor suppressing effects of various anti-cancer drugs. The aim of our work is to perfom the basic experiments in tissue cultures, confirm their results in laboratory mice and to participate in clinical studies to provide benefits to cancer patients.
Latest news
New paper !!!
2nd March 2012
Knopfova L, Benes P, Pekarcikova L, Hermanova M, Masarik M, Pernicova Z, Soucek K, Smarda J. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: Implications for matrix-dependent breast cancer cell invasion and metastasis. Mol Cancer 2012, in press.
Happy new year
4th January 2012
Dear friends, colleagues and visitors, we take this opportunity to wish you and your family members health, happiness, prosperity and success in the coming year.
2011 Babyboooom !!!
25th May 2011
To our knowledge, 6 (former or present) members of our lab is going to have a baby in 2011.
Congratulations!
* April 2nd - Vitecek Ondrousek
* May 13th - Amalka Pelkova
* June 1st - Maruska Prochazkova
* June 26th - Emmicka Navratilova
* July 4th - Emicka Vanharova
* December 14th - Edik Slovacek
