Laboratory of Cell Differentiation

The laboratory was established in 1994 to investigate principles of proliferation, differentiation, migration and programmed cell death of cancer cells. As a model we use cancer cell lines of various origin (breast, colon, lung, leukemia etc). Using multiple techniques of molecular and cellular biology, we investigate function of specific genes and the role of tumor microenvironment in these processes. We are also interested in testing the tumor suppressing effects of various anti-cancer drugs. The aim of our work is to perfom the basic experiments in tissue cultures, confirm their results in laboratory mice and to participate in clinical studies to provide benefits to cancer patients.

Latest news

New paper !!!

12th May 2016

Pekarčíková L, Knopfová L, Beneš P, Šmarda J. c-Myb regulates NOX1/p38 to control survival of colorectal carcinoma cells. Cell Signal. 2016; doi: 10.1016/j.cellsig.2016.04.007.

New paper !!!

14th April 2016

Jancekova B, Ondrouskova E, Knopfova L, Smarda J, Benes P. Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL. Tumour Biol 2016; doi: 10.​1007/​s13277-016-4958-5.

New Paper !!!

14th April 2016

Tichý M, Knopfová L, Jarkovský J, Pekarčíková L, Veverková L, Vlček P, Katolická J, Čapov I, Hermanová M, Šmarda J, Beneš P. Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma. Tumour Biol 2016; doi: 10.1007/s13277-016-4956-7.