The laboratory was established in 1994 to investigate principles of proliferation, differentiation, migration and programmed cell death of cancer cells. As a model we use cancer cell lines of various origin (breast, colon, lung, leukemia etc). Using multiple techniques of molecular and cellular biology, we investigate function of specific genes and the role of tumor microenvironment in these processes. We are also interested in testing the tumor suppressing effects of various anti-cancer drugs. The aim of our work is to perfom the basic experiments in tissue cultures, confirm their results in laboratory mice and to participate in clinical studies to provide benefits to cancer patients.
17th January 2017
Navrátilová J, et al. Selective elimination of neuroblastoma cells by synergistic effect of Akt kinase inhibitor and tetrathiomolybdate. J Cell Mol Med 2017; in press.
12th May 2016
Pekarčíková L, Knopfová L, Beneš P, Šmarda J. c-Myb regulates NOX1/p38 to control survival of colorectal carcinoma cells. Cell Signal. 2016; doi: 10.1016/j.cellsig.2016.04.007.
14th April 2016
Jancekova B, Ondrouskova E, Knopfova L, Smarda J, Benes P. Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL. Tumour Biol 2016; doi: 10.1007/s13277-016-4958-5.