RNDr. Petr Chlapek, DiS., Ph.D.

Assistant professor, Section of Genetics and Molecular Biology

Office: bldg. C13/316
Kamenice 753/5
625 00 Brno

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Phone: +420 549 49 3970

Curriculum Vitae

Person-Related Identification Information
  • RNDr. Petr Chlapek, DiS., Ph.D.
  • Department of Genetics and Molecular Biology
    Masaryk University
    Faculty of Science
    Kotlarska 2
    61137 Brno
    Czech Republic
Employment - Position
  • Assistant Professor
Education and Academic Qualifications
  • 2012: PhD, Masaryk University in Brno, Faculty of Science, Study program: Molecular and Cell Biology
  • 2007: Mgr./ RNDr., Masaryk University in Brno, Faculty of Science, Study program: Physiology of Animals
  • 2005: Bc., University of Ostrava, Faculty of Science, Study program: Systematic Biology and Ecology
  • 2002: DiS., Tertiary technical school, Kostelec nad Orlici, Study program: Breeding of Animals
  • Masaryk University, School of Science, Department of Experimental Biology (Brno, Czech Republic): Researcher (2007 – 2014), Assistant Professor (since 2014)
  • St. Anne’s University Hospital, International Clinical Research Center (Brno, Czech Republic): Postdoctoral Researcher (since 2015)
  • First Department of Pathological Anatomy, St. Anne’s University Hospital (Brno, Czech Republic): FISH specialist (2011 – 2014)
Teaching Activities
  • Bi8920c Fluorescence Microscopy - practicals
  • Bi1700c Cell Biology - Practical Course
  • Bi3338/9 Seminar of specialisation Molecular Biology and Genetics
  • Bi0952 Bioethics - Seminar
  • Bi0954 Bioethics - Online Case Studies

  • Katerina Adamkova, Viera Slavikova, Lucie Curylova, Terezie Dvorakova, Aneta Vaskova

  • Viera Slavikova, Lenka Filipova, Katerina Adamkova, Lucie Curylova, Adriana Ladungova, Terezie Dvorakova

  • Viera Slavikova

  • Liliana Raimundo (PhD student in BiotechHealth UCIBIO/REQUIMTE, Faculty of Pharmacy of University of Porto)
  • Helena Ramos (PhD Student – LAQV/REQUIMTE, Faculty of Pharmacy of University of Porto)
Scientific and Research Activities
  • Therapeutic potential of novel thiosemicarbazones in pediatric oncology: the possibilities how to overcome Pgp-mediated drug resistance (Grant No. 17-33104A of the Ministry of Healthcare of the Czech Republic; duration: 2017-2020; principal investigator: R. Veselska)
  • ENOCH – Molecular, Cellular and Clinical Approach to Healthy Ageing (Project OP VVV CZ.02.1.01/0.0/0.0/16_019/0000868; duration: 2018-2022; principal investigator: Gorazd Bernard Stokin)
  • Translational Medicine (Project NPU II LQ1605; duration: 2016-2020; principal investigator: Gorazd Bernard Stokin)
  • Candidate biomarkers of resistance to retinoids in children with high-risk neuroblastoma (Grant No. 15-34621A of the Ministry of Healthcare of the Czech Republic; duration: 2015-2018; principal investigator: R. Veselska)
  • IntegRECAMO: Intellectual Anchor (Project OP VK CZ.1.07/2.3.00/20.0097; duration: 2012-2015; principal investigator: D. Valik)
  • Center of Experimental Biomedicine (CEB) (Project OP VK CZ.1.07/2.3.00/20.0183; duration: 2012-2015; principal investigator: J. Smarda)
Academical Stays
  • School of Medical Sciences, Department of Pathology, University of Sydney, Australia (2019)
  • UCIBIO/REQUIMTE, Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto, Portugal (2018)
  • Newman-Lakka Institute for Personalized Cancer Care, Floating Hospital for Children at Tufts Medical Center, Boston, USA (2014)
University Activities
  • Member of the Research Ethics Committee – Masaryk University (since 2015)
Major Publications
  • GOMES, Sara, Liliana Sofia Gomes RAIMUNDO, Joana SOARES, Joana B. LOUREIRO, Mariana LEAO, Helena Isabel NOGUEIRA RAMOS ROCHA, Madalena N. MONTEIRO, Agostinho LEMOS, Joana MOREIRA, Madalena PINTO, Petr CHLAPEK, Renata VESELSKÁ, Emília SOUSA a Lucília SARAIVA. New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma. Cancer Letters. County Clare: ELSEVIER IRELAND LTD, 2019, roč. 446, č. 4, s. 90-102. ISSN 0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2019.01.014. Full Text info
  • DOBROTKOVÁ, Viera, Petr CHLAPEK, Marta JEŽOVÁ, Kateřina ADÁMKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers. PLOS ONE. San Francisco: Public Library of Science, 2019, roč. 14, č. 6, s. 1-18. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0218269. URL info
  • VESELSKÁ, Renata, Marta JEŽOVÁ, Michal KÝR, Pavel MAZÁNEK, Petr CHLAPEK, Viera DOBROTKOVÁ a Jaroslav ŠTĚRBA. Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy. Frontiers in Oncology. Lausanne: Frontiers Media SA, 2019, roč. 9, NOV 15, s. 1-12. ISSN 2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2019.01221. URL info
  • CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, roč. 19, č. 1, s. nestránkováno, 14 s. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19010132. URL info
  • DOBROTKOVÁ, Viera, Petr CHLAPEK, Pavel MAZÁNEK, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy. BMC Cancer. London: BioMed Central, 2018, roč. 18, č. 1059, s. nestránkováno, 13 s. ISSN 1471-2407. Dostupné z: https://dx.doi.org/10.1186/s12885-018-4966-5. URL info
  • CHLAPEK, Petr, Karel ZITTERBART, Leoš KŘEN, Lenka FILIPOVÁ, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups. PLOS ONE. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2017, roč. 12, č. 2, s. nestránkováno, 14 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0172552. URL info
  • CHLAPEK, Petr, Jakub NERADIL, Martina LOJOVÁ, Karel ZITTERBART, Jaroslav ŠTĚRBA a Renata VESELSKÁ. The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression. Cancer Cell International. 2014, roč. 14, June, s. "nestránkováno", 10 s. ISSN 1475-2867. Dostupné z: https://dx.doi.org/10.1186/1475-2867-14-51. URL info
  • KRZYŽÁNKOVÁ, Miroslava, Silvia CHOVANOVÁ, Petr CHLAPEK, Matěj RÁDSETOULAL, Jakub NERADIL, Karel ZITTERBART, Jaroslav ŠTĚRBA a Renata VESELSKÁ. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. Tumor Biology. Dordrecht: Springer, 2014, roč. 35, č. 8, s. 7617-7627. ISSN 1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-014-2019-5. URL info
  • CHLAPEK, Petr, Silvia CHOVANOVÁ, Viera SLÁVIKOVÁ a Renata VESELSKÁ. Mikroprostředí nádoru – možnosti výzkumu v podmínkách in vitro. Klinická onkologie. Brno: C̆eská onkologická spolec̆nost, 2014, roč. 27, Suppl 1, s. "S48"-"S52", 5 s. ISSN 0862-495X. info
  • ŠÁNA, Jiří, Iva ZAMBO, Jan ŠKODA, Jakub NERADIL, Petr CHLAPEK, Markéta HERMANOVÁ, Peter MÚDRY, Alzbeta VASIKOVA, Karel ZITTERBART, Aleš HAMPL, Jaroslav ŠTĚRBA a Renata VESELSKÁ. CD133 expression and identification of CD133/nestin positive cells in rhabdomyosarcomas and rhabdomyosarcoma cell lines. Analytical Cellular Pathology-Cellular Oncology. 2011, roč. 34, č. 6, s. 303–318. ISSN 2210-7177. Dostupné z: https://dx.doi.org/10.3233/ACP-2011-0018. info
  • RÉDOVÁ, Martina, Petr CHLAPEK, Tomáš LOJA, Karel ZITTERBART, Markéta HERMANOVÁ, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines. International Journal of Molecular Medicine. Athens: Spandidos Ltd., 2010, roč. 25, č. 2, s. 271-280. ISSN 1107-3756. info
  • CHLAPEK, Petr, Martina RÉDOVÁ, Karel ZITTERBART, Markéta HERMANOVÁ, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study. Journal of Experimental and Clinical Cancer Research. London: BioMed Central Ltd., 2010, roč. 29, č. 45, 8 s. ISSN 1756-9966. info
  • LOJA, Tomáš, Petr CHLAPEK, Petr KUGLÍK, Martina PEŠÁKOVÁ, Alexandra OLTOVÁ, Pavel CEJPEK a Renata VESELSKÁ. Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin. Oncology Reports. 2009, roč. 21, č. 1, s. 119-127. ISSN 1021-335X. info
  • VESELSKÁ, Renata, Markéta HERMANOVÁ, Tomáš LOJA, Petr CHLAPEK, Iva ZAMBO, Karel VESELÝ, Karel ZITTERBART a Jaroslav ŠTĚRBA. Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. BMC Cancer. 2008, roč. 8, č. 300, 8 s. ISSN 1471-2407. URL info


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