Ing. Pavel Kohout, Ph.D.

2025

• Anticipating protein evolution with successor sequence predictor

  KHAN Rayyan Tariq KOHOUT Pavel MUSIL Miloš ROSINSKÁ Monika DAMBORSKÝ Jiří MAZURENKO Stanislav BEDNÁŘ David

  Peer-reviewed scientific article

  Journal of Cheminformatics, year: 2025, volume: 17, edition: 1, DOI

• Assessing the impact of His-tags on activity and stability of staphylokinase variants

  STULAJTEROVA Monika AMBRO Lubos SEDLAKOVA Dagmar NEMERGUT Michal KOHOUT Pavel MAZURENKO Stanislav VARHAC Rastislav STRUNGA Alan TOUL Martin PROKOP Zbyněk DAMBORSKÝ Jiří TOMKOVA Maria SEDLÁK Erik

  Peer-reviewed scientific article

  International Journal of Biological Macromolecules, year: 2025, volume: 328, edition: November 2025, DOI

• Caver Web 2.0: analysis of tunnels and ligand transport in dynamic ensembles of proteins

  MARQUES Sérgio Manuel BORKO Simeon VÁVRA Ondřej DVORSKÝ Jan KOHOUT Pavel KABOUREK Petr HEJTMÁNEK Lukáš DAMBORSKÝ Jiří BEDNÁŘ David

  Peer-reviewed scientific article

  Nucleic Acids Research, year: 2025, volume: 53, edition: W1, DOI

• Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics

  KOHOUT Pavel VAŠINA Michal MAJEROVÁ Marika NOVÁKOVÁ Veronika DAMBORSKÝ Jiří BEDNÁŘ David MAREK Martin PROKOP Zbyněk MAZURENKO Stanislav

  Peer-reviewed scientific article

  JACS Au, year: 2025, volume: 5, edition: 2, DOI

2024

• Successor Sequence Predictor (SSP)

  KHAN Rayyan Tariq KOHOUT Pavel MUSIL Miloš ROSÍNSKÁ Monika DAMBORSKÝ Jiří MAZURENKO Stanislav BEDNÁŘ David VILÍM Jan

  Software

  Year: 2024

• Variační nástroj založený na autoenkodéru pro návrh ancestrálních proteinů

  KOHOUT Pavel DAMBORSKÝ Jiří BEDNÁŘ David

  Software

  Year: 2024

2023

• Machine Learning-Guided Protein Engineering

  KOUBA Petr KOHOUT Pavel HADDADI Faraneh BUSHUIEV Anton SAMUSEVICH Raman SEDLAR Jiri DAMBORSKÝ Jiří PLUSKAL Tomáš SIVIC Josef MAZURENKO Stanislav

  Peer-reviewed scientific article

  ACS Catalysis, year: 2023, volume: 13, edition: 21, DOI