Gene Diagnostics and Therapy of Multiform Glioblastoma (COST)

Project Identification
OC B19.001
Project Period
1/2001 - 9/2006
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
MU Faculty or unit
Faculty of Medicine
Other MU Faculty/Unit
Faculty of Science
Keywords
Gene Diagnostics, Therapy, Multiform Glioblastoma

The substance of the project consists in a precise selective removal of tumor tissue from different parts of the brain tumor by means of computer-navigated stereotaxis, and subsequent molecular-genetic processing of samples of tumor tissue. The aim is to obtain data on the types of genetic abnormalities from different parts of multiform glioblastoma, and to acquire new knowledge that could be used in its treatment. Another aim of the project is to develop and apply new methods and technologies (e.g. FISH # fluorescence in-situ hybridization, CGH # comparative genomic hybridization) employed in the detection of structural and numerical defects of chromosomes in the solution of problems of GBM. A special point of the study will be the correlation between deletions, hyperdiploid or amplification types and translocations of genetic material, and the prognostic significance of these specific findings in GBM.

Publications

Total number of publications: 18


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