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Project information
Characterization of autologous T cell clones reactive against metastatic melanoma

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.
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Project Identification
GA301/04/1387
Project Period
1/2004 - 12/2006
Investor / Pogramme / Project type
Czech Science Foundation
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MU Faculty or unit
Faculty of Medicine
Keywords
T cell, clone, melanoma

The objective of this proposal is to ident´fy and characterize autologous T cells that are able to specifically destroy tumor cells from patients with metastatic melanoma. Melanoma cell apoptotic bodies-pulsed dentritic cells will be used to activate autologous T cells. Melanoma-specific T cells will be activated andsorted out by flow cytometer. Clonality of these activated T cells will be studied using cDNA library and direct sequenciong of T cell receptor beta genes. Melanoma-specific T cell clones will be identified, quantified, expanded, tested for cytotoxicity against original melanoma cells, and potentially use in future clicical studies.

Publications

Total number of publications: 5

2007

2006

2005

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