Genome-wide integrative analysis of DNA methylation and transcriptional expression of different lineages of Treponema pallidum subsp. pallidum, the causative agents of syphilis

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification
MUNI/11/SUP/04/2020
Project Period
10/2020 - 1/2021
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Syphilis, caused by the bacterium Treponema pallidum subsp. pallidum (TPA) is considered a re-emerging disease with over 5.6 million cases worldwide. Despite causing severe life-threatening infections, very little is known about the basic biology of TPA. The goal of this research proposal is to link in vitro and in vivo cultivation to genomic approaches to provide unique insights into the gene expression and epigenetic profiles of this pathogen. We will characterize differential transcriptomic responses of TPA and characterize how the transcriptomic responses correlate with the DNA methylation pattern. This should provide valuable information for the understanding of the basic biology of pathogenic treponemes that has not been previously studied.

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