Project information
Derivatization strategies revealing metabolic patterns in human pluripotent stem cells and progenitors by mass spectrometry (Stem cells metabolites derivatization)

Project Identification

MUNI/IGA/1208/2021

Project Period

1/2022 - 12/2022

Investor / Pogramme / Project type

Masaryk University

Internal grant agency MU

MU Faculty or unit

Faculty of Science

Mgr. Lukáš Pečinka, Ph.D.

Metabolites are intermediate or terminal products of cell biochemical pathways. Changes in metabolites reflect the state of cell physiology, including proliferation or differentiation. The proposed project will use one-step chemical derivatization for mass spectrometry detection of different metabolites to reveal metabolic states of pluripotent stem cells and derivatives in standard 2D (in solution derivatization) and advanced 3D cultures of stem cells and derivatives (on tissue derivatization).

Publications

Total number of publications: 2

2022

DERIVATIZATION STRATEGIES FOR SENSITIVE MONITORING OF SMALL MOLECULES ON TISSUE SAMPLES

PEČINKA Lukáš BŘEZINA Adam MORÁŇ Lukáš VESSELÁ Tereza GABRIELOVÁ Viktorie FARKOVÁ Marta ROBL Bernhard HAVEL Josef MARCHETTI-DESCHMANN Martina HAMPL Aleš VAŇHARA Petr

Conference abstract

Year: 2022, type: Conference abstract
ONE STEP CHEMICAL DERIVATIZATION OF SECRETED CELL METABOLITES FOR SENSITIVE MASS SPECTROMETRY DETECTION

PEČINKA Lukáš MORÁŇ Lukáš POROKH Volodymyr MARCHETTI-DESCHMANN Martina HAVEL Josef HAMPL Aleš VAŇHARA Petr

Conference abstract

Year: 2022, type: Conference abstract

Project informationDerivatization strategies revealing metabolic patterns in human pluripotent stem cells and progenitors by mass spectrometry (Stem cells metabolites derivatization)

Publications

2022

Project information
Derivatization strategies revealing metabolic patterns in human pluripotent stem cells and progenitors by mass spectrometry (Stem cells metabolites derivatization)