Structural characterization of intrinsically disordered region of Carbonic anhydrase IX

Project Identification
MUNI/IGA/1196/2021
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Science

Carbonic anhydrase IX (CAIX) is a transmembrane metalloenzyme that contributes to the regulation of the pH outside and inside the cell and is often upregulated in cancer cells. CAIX has a unique disordered region (IDR) that plays a key role in both catalytic and noncatalytic activity of CAIX, yet there is little known about its structure. This project will provide detailed structural information about the IDR of CAIX which could elucidate its influence on CAIX activity.

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