Multi-omic analysis of molecular mechanisms underlying the effects of casein kinase 1 inhibition in treatment of chronic lymphocytic leukaemia

Project Identification
MUNI/IGA/1176/2021
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Science

Chronic lymphocytic leukaemia (CLL) is a common haematological malignancy without defined optimal treatment approach. Recently, it was shown that CK1 inhibition has beneficial effects on prognosis of tested individuals and unlike other approaches, it does not result in immune toxicity. This study is focused on the multi-omic analysis of molecular mechanisms underlying beneficial effects of CK1 inhibition on repression of CLL. The main hypotheses will be validated via flow cytometry and RNASeq.

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