RNDr. Petr Chlapek, DiS., Ph.D.

Curriculum Vitae

Person-Related Identification Information

• RNDr. Petr Chlapek, DiS., Ph.D.

Workplace

• Department of Genetics and Molecular Biology
  Masaryk University
  Faculty of Science
  Kotlarska 2
  61137 Brno
  Czech Republic

Employment - Position

• Assistant Professor

Education and Academic Qualifications

• 2012: PhD, Masaryk University in Brno, Faculty of Science, Study program: Molecular and Cell Biology
• 2007: Mgr./ RNDr., Masaryk University in Brno, Faculty of Science, Study program: Physiology of Animals
• 2005: Bc., University of Ostrava, Faculty of Science, Study program: Systematic Biology and Ecology
• 2002: DiS., Tertiary technical school, Kostelec nad Orlici, Study program: Breeding of Animals

Employment

• Masaryk University, School of Science, Department of Experimental Biology (Brno, Czech Republic): Researcher (2007 – 2014), Assistant Professor (since 2014)
• St. Anne’s University Hospital, International Clinical Research Center (Brno, Czech Republic): Postdoctoral Researcher (since 2015)
• First Department of Pathological Anatomy, St. Anne’s University Hospital (Brno, Czech Republic): FISH specialist (2011 – 2014)

Teaching Activities

• Bi8920c Fluorescence Microscopy - practicals
• Bi1700c Cell Biology - Practical Course
• Bi3338/9 Seminar of specialisation Molecular Biology and Genetics
• Bi0952 Bioethics - Seminar
• Bi0954 Bioethics - Online Case Studies
  
  SUPERVISOR OF B.Sc. THESES:
• Katerina Adamkova, Viera Slavikova, Lucie Curylova, Terezie Dvorakova, Aneta Vaskova
  
  SUPERVISOR OF M.Sc. THESES:
• Viera Slavikova, Lenka Filipova, Katerina Adamkova, Lucie Curylova, Adriana Ladungova, Terezie Dvorakova
  
  SUPERVISOR OF Ph.D. THESES:
• Viera Slavikova
  
  ASSISTANCE TO ERASMUS STUDENTS:
• Liliana Raimundo (PhD student in BiotechHealth UCIBIO/REQUIMTE, Faculty of Pharmacy of University of Porto)
• Helena Ramos (PhD Student – LAQV/REQUIMTE, Faculty of Pharmacy of University of Porto)

Scientific and Research Activities

• Therapeutic potential of novel thiosemicarbazones in pediatric oncology: the possibilities how to overcome Pgp-mediated drug resistance (Grant No. 17-33104A of the Ministry of Healthcare of the Czech Republic; duration: 2017-2020; principal investigator: R. Veselska)
• ENOCH – Molecular, Cellular and Clinical Approach to Healthy Ageing (Project OP VVV CZ.02.1.01/0.0/0.0/16_019/0000868; duration: 2018-2022; principal investigator: Gorazd Bernard Stokin)
• Translational Medicine (Project NPU II LQ1605; duration: 2016-2020; principal investigator: Gorazd Bernard Stokin)
• Candidate biomarkers of resistance to retinoids in children with high-risk neuroblastoma (Grant No. 15-34621A of the Ministry of Healthcare of the Czech Republic; duration: 2015-2018; principal investigator: R. Veselska)
• IntegRECAMO: Intellectual Anchor (Project OP VK CZ.1.07/2.3.00/20.0097; duration: 2012-2015; principal investigator: D. Valik)
• Center of Experimental Biomedicine (CEB) (Project OP VK CZ.1.07/2.3.00/20.0183; duration: 2012-2015; principal investigator: J. Smarda)

Academical Stays

• School of Medical Sciences, Department of Pathology, University of Sydney, Australia (2019)
• UCIBIO/REQUIMTE, Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto, Portugal (2018)
• Newman-Lakka Institute for Personalized Cancer Care, Floating Hospital for Children at Tufts Medical Center, Boston, USA (2014)

University Activities

• Member of the Research Ethics Committee – Masaryk University (since 2015)

Major Publications

• GOMES, Sara; Liliana Sofia Gomes RAIMUNDO; Joana SOARES; Joana B. LOUREIRO; Mariana LEAO; Helena Isabel NOGUEIRA RAMOS ROCHA; Madalena N. MONTEIRO; Agostinho LEMOS; Joana MOREIRA; Madalena PINTO; Petr CHLAPEK; Renata VESELSKÁ; Emília SOUSA a Lucília SARAIVA. New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma. Cancer Letters. County Clare: ELSEVIER IRELAND LTD, 2019, roč. 446, č. 4, s. 90-102. ISSN 0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2019.01.014. Full Text info
• DOBROTKOVÁ, Viera; Petr CHLAPEK; Marta JEŽOVÁ; Kateřina ADÁMKOVÁ; Pavel MAZÁNEK; Jaroslav ŠTĚRBA a Renata VESELSKÁ. Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers. PLOS ONE. San Francisco: Public Library of Science, 2019, roč. 14, č. 6, s. 1-18. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0218269. URL info
• VESELSKÁ, Renata; Marta JEŽOVÁ; Michal KÝR; Pavel MAZÁNEK; Petr CHLAPEK; Viera DOBROTKOVÁ a Jaroslav ŠTĚRBA. Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy. Frontiers in Oncology. Lausanne: Frontiers Media SA, 2019, roč. 9, NOV 15, s. 1-12. ISSN 2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2019.01221. URL info
• CHLAPEK, Petr; Viera SLÁVIKOVÁ; Pavel MAZÁNEK; Jaroslav ŠTĚRBA a Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, roč. 19, č. 1, s. nestránkováno, 14 s. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19010132. URL info
• DOBROTKOVÁ, Viera; Petr CHLAPEK; Pavel MAZÁNEK; Jaroslav ŠTĚRBA a Renata VESELSKÁ. Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy. BMC Cancer. London: BioMed Central, 2018, roč. 18, č. 1059, s. nestránkováno, 13 s. ISSN 1471-2407. Dostupné z: https://dx.doi.org/10.1186/s12885-018-4966-5. URL info
• CHLAPEK, Petr; Karel ZITTERBART; Leoš KŘEN; Lenka FILIPOVÁ; Jaroslav ŠTĚRBA a Renata VESELSKÁ. Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups. PLOS ONE. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2017, roč. 12, č. 2, s. nestránkováno, 14 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0172552. URL info
• CHLAPEK, Petr; Jakub NERADIL; Martina LOJOVÁ; Karel ZITTERBART; Jaroslav ŠTĚRBA a Renata VESELSKÁ. The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression. Cancer Cell International. 2014, roč. 14, June, s. "nestránkováno", 10 s. ISSN 1475-2867. Dostupné z: https://dx.doi.org/10.1186/1475-2867-14-51. URL info
• KRZYŽÁNKOVÁ, Miroslava; Silvia CHOVANOVÁ; Petr CHLAPEK; Matěj RÁDSETOULAL; Jakub NERADIL; Karel ZITTERBART; Jaroslav ŠTĚRBA a Renata VESELSKÁ. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. Tumor Biology. Dordrecht: Springer, 2014, roč. 35, č. 8, s. 7617-7627. ISSN 1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-014-2019-5. URL info
• CHLAPEK, Petr; Silvia CHOVANOVÁ; Viera SLÁVIKOVÁ a Renata VESELSKÁ. Mikroprostředí nádoru – možnosti výzkumu v podmínkách in vitro. Klinická onkologie. Brno: C̆eská onkologická spolec̆nost, 2014, roč. 27, Suppl 1, s. "S48"-"S52", 5 s. ISSN 0862-495X. info
• ŠÁNA, Jiří; Iva ZAMBO; Jan ŠKODA; Jakub NERADIL; Petr CHLAPEK; Markéta HERMANOVÁ; Peter MÚDRY; Alzbeta VASIKOVA; Karel ZITTERBART; Aleš HAMPL; Jaroslav ŠTĚRBA a Renata VESELSKÁ. CD133 expression and identification of CD133/nestin positive cells in rhabdomyosarcomas and rhabdomyosarcoma cell lines. Analytical Cellular Pathology-Cellular Oncology. 2011, roč. 34, č. 6, s. 303–318. ISSN 2210-7177. Dostupné z: https://dx.doi.org/10.3233/ACP-2011-0018. info
• RÉDOVÁ, Martina; Petr CHLAPEK; Tomáš LOJA; Karel ZITTERBART; Markéta HERMANOVÁ; Jaroslav ŠTĚRBA a Renata VESELSKÁ. Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines. International Journal of Molecular Medicine. Athens: Spandidos Ltd., 2010, roč. 25, č. 2, s. 271-280. ISSN 1107-3756. info
• CHLAPEK, Petr; Martina RÉDOVÁ; Karel ZITTERBART; Markéta HERMANOVÁ; Jaroslav ŠTĚRBA a Renata VESELSKÁ. Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study. Journal of Experimental and Clinical Cancer Research. London: BioMed Central Ltd., 2010, roč. 29, č. 45, 8 s. ISSN 1756-9966. info
• LOJA, Tomáš; Petr CHLAPEK; Petr KUGLÍK; Martina PEŠÁKOVÁ; Alexandra OLTOVÁ; Pavel CEJPEK a Renata VESELSKÁ. Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin. Oncology Reports. 2009, roč. 21, č. 1, s. 119-127. ISSN 1021-335X. info
• VESELSKÁ, Renata; Markéta HERMANOVÁ; Tomáš LOJA; Petr CHLAPEK; Iva ZAMBO; Karel VESELÝ; Karel ZITTERBART a Jaroslav ŠTĚRBA. Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. BMC Cancer. 2008, roč. 8, č. 300, 8 s. ISSN 1471-2407. URL info

2020/09/24