Propojení funkce Sprouty s FGF a primárními ciliemi ve vývoji

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Project Identification
GA21-04178S
Project Period
1/2021 - 12/2023
Investor / Pogramme / Project type
Czech Science Foundation
MU Faculty or unit
Faculty of Science
Cooperating Organization
Institute of Animal Physiology and Genetics of thr ASCR, v. v. i.
Charles University

Sprouty proteins provide a control mechanism for appropriate receptor tyrosine kinase signaling, including FGF signaling pathway. Deficiencies in mouse Sprouties cause developmental abnormalities leading to hearing impairment, craniofacial defects, retarded postnatal growth or esophageal achalasia and intestinal pseudo-obstruction. In human, Sprouty2 has been identified to play a role in nephropathy, thanatophoric dysplasia and different types of cancer. Interestingly, fibroblast growth factor (FGF) signaling hyperactivation
syndromes and syndromes associated with primary cilia dysfunction share a range of common phenotypic manifestations, beside others, craniofacial and achondroplasia malformations. The project aims to characterize Sprouty proteins role during process of skeletogenesis. Further, we will analyze mouse model with deletion of Sprouty2 and Sprouty 4 to determine tissues and
organs developmental defects implicated in ciliopathies and evaluate primary cilia associated signaling during morphogenesis in Sprouty deficient mice.

Publications

Total number of publications: 1


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