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Latest Publications from Our Section

An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice
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Abstract: Achondroplasia is the most prevalent genetic form of dwarfism in humans and is caused by activating mutations in FGFR3 tyrosine kinase. The clinical need for a safe and effective inhibitor of FGFR3 is unmet, leaving achondroplasia currently incurable. Here, … Read More

Methodology for the Implementation of Internal Standard to Laser-Induced Breakdown Spectroscopy Analysis of Soft Tissues
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Abstract: The improving performance of the laser-induced breakdown spectroscopy (LIBS) triggered its utilization in the challenging topic of soft tissue analysis. Alterations of elemental content within soft tissues are commonly assessed and provide further insights in biological research. However, the … Read More

A cellular and spatial map of the choroid plexus across brain ventricles and ages
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Abstract: The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. Authors: Neil Dani … Read More

Changes in haemolymph parameters and insect ability to respond to immune challenge during overwintering
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Abstract: Overwintering is a challenging period in the life of temperate insects. A limited energy budget characteristic of this period can result in reduced investment in immune system. Here, we investigated selected physiological and immunological parameters in laboratory-reared and field-collected … Read More

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
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Abstract: Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β. However, gaps exist in our understanding of how cilia formation and function is … Read More

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome
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Abstract: Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture … Read More