Analysis of tissue response to metal nanoparticles inhalation and mechanisms of their clearance
- Kód projektu
- GA20-02203S
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Spolupracující organizace
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Ústav analytické chemie AV ČR, v. v. i.
- Odpovědná osoba , RNDr. Pavel, Mikuška, CSc.
- Odpovědná osoba doc. RNDr. Marcela Buchtová, Ph.D.
The proposed project is focused on the influence of inhaled metal nanoparticles (soluble and semi-soluble form of metal) presented in urban aerosol on experimental animals and on the accumulation and subsequent elimination of metal nanoparticles from selected organs of exposed animals. In proposed project, we will expose female mice to nanoparticles containing lead or cadmium compounds by inhalation in a whole body inhalation chamber representing physiological form of exposure similar to real air conditions.
The aim of this project is to deepen the basic knowledge gained from previous inhalation experiments of nanoparticles of semi-soluble PbO and CdO. In context, that there is no known safe exposure to lead, and inorganic soluble form of lead is supposed to be probably carcinogenic to humans, the question of lead nanoparticle effect on living organisms and its clearing mechanisms are key for the prevention of stress responses of exposed cells
Publikace
Počet publikací: 8
2022
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Ilaps - python software for data reduction and imaging with LA-ICP-MS
Journal of Analytical Atomic Spectrometry, rok: 2022, ročník: 37, vydání: 4, DOI
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IMAGING OF ELEMENTS AND PROTEINS IN BIOLOGICAL TISSUES: MEDICAL AND PHARMACEUTICAL APPLICATIONS
Rok: 2022, druh: Další prezentace na konferencích
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Laser ablation imaging in bioapplications
Rok: 2022, druh: Vyžádané přednášky
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Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters
Particle and Fibre Toxicology, rok: 2022, ročník: 19, vydání: 1, DOI
2021
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Cytoskeletal changes and reparative processes in brain exposed to metal nanoparticles
Rok: 2021, druh: Konferenční abstrakty
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Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS
BioMed Research International, rok: 2021, ročník: 2021, vydání: October 2021, DOI
2020
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A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response
International Journal of Molecular Sciences, rok: 2020, ročník: 21, vydání: 22, DOI
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Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters
ACS Nano, rok: 2020, ročník: 14, vydání: 3, DOI