Analysis of tissue response to metal nanoparticles inhalation and mechanisms of their clearance
- Project Identification
- GA20-02203S
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
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Institute of Analytical Chemistry of the ASCR, v. v. i.
- Responsible person , RNDr. Pavel, Mikuška, CSc.
- Responsible person doc. RNDr. Marcela Buchtová, Ph.D.
The proposed project is focused on the influence of inhaled metal nanoparticles (soluble and semi-soluble form of metal) presented in urban aerosol on experimental animals and on the accumulation and subsequent elimination of metal nanoparticles from selected organs of exposed animals. In proposed project, we will expose female mice to nanoparticles containing lead or cadmium compounds by inhalation in a whole body inhalation chamber representing physiological form of exposure similar to real air conditions.
The aim of this project is to deepen the basic knowledge gained from previous inhalation experiments of nanoparticles of semi-soluble PbO and CdO. In context, that there is no known safe exposure to lead, and inorganic soluble form of lead is supposed to be probably carcinogenic to humans, the question of lead nanoparticle effect on living organisms and its clearing mechanisms are key for the prevention of stress responses of exposed cells
Publications
Total number of publications: 7
2022
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Ilaps - python software for data reduction and imaging with LA-ICP-MS
Journal of Analytical Atomic Spectrometry, year: 2022, volume: 37, edition: 4, DOI
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IMAGING OF ELEMENTS AND PROTEINS IN BIOLOGICAL TISSUES: MEDICAL AND PHARMACEUTICAL APPLICATIONS
Year: 2022, type: Appeared in Conference without Proceedings
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Laser ablation imaging in bioapplications
Year: 2022, type:
2021
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Cytoskeletal changes and reparative processes in brain exposed to metal nanoparticles
Year: 2021, type: Conference abstract
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Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS
BioMed Research International, year: 2021, volume: 2021, edition: October 2021, DOI
2020
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A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response
International Journal of Molecular Sciences, year: 2020, volume: 21, edition: 22, DOI
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Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters
ACS Nano, year: 2020, volume: 14, edition: 3, DOI