prof. Mgr. Jiří Damborský, Dr.

vedoucí pracoviště – Loschmidtovy laboratoře
vedoucí pracoviště – Molekulární modelování a bioinformatika


kancelář: bud. A13/225
Kamenice 753/5
625 00 Brno

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telefon: 549 49 3467
e‑mail:
Životopis

Curriculum Vitae

Person Identification
  • Dr. Jiří Damborský
    born September 29, 1969 in Bílovec, Czech Republic
Affiliation and Address
  • Loschmidt Laboratories
    Department of Experimental Biology
    Research Centre for Toxic Compounds in the Environment
    Faculty of Science, Masaryk University
    Kamenice 5/A13, 625 00 Brno, Czech Republic
Employment Position
  • Professor
Education and Academic Qualifications
  • 2011: Prof., Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 2004: Doc., Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 1997: Ph.D., Department of Microbiology, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 1993: MSc., Department of Microbiology, Faculty of Science, Masaryk University, Brno, Czech Republic
Employment Summary
  • 2011-now: Professor, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 2011-now: Professor, International Centre for Clinical Research, Brno, Czech Republic
  • 2004-2010: Associate Professor, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 1997-2003: National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic
Pedagogical Activities
  • Bioinformatics; Protein Structure and Function; Structural Biochemistry; Professional English for Molecular Biologists; Introduction to the study of Special Biology; Summer School of Protein Engineering
Research Projects
  • 2017-2018: Horizon 2020 Widespread Teaming; CETOCOEN Excellence; 763677
  • 2017-2020: Grant Technological Agency of Czech Republic; Production of Stable Fibroblast Growth Factors for Research, Therapeutic and Cosmetic Applications; TH02010219
  • 2017-2019: Horizon 2020 SME Instrument; Industrial Production of Stable Fibroblast Growth Factors for Regenerative Medicine and Related Research; 756471
  • 2017-2020: Horizon 2020 Industrial Leadership; Synthetic Bacterial Lipid Rafts to Optimize Industrial Bioprocesses; 720776
  • 2017-2020: Horizon 2020 International Training Network; Directed Protein Evolution for Synthetic Biology and Biocatalysis; 722610
  • 2016-2022: Grant of the Ministry of Education of Czech Republic ESFRI; Czech National Infrastructure for Biological Data; LM2015047
  • 2015-2020: Grant of the Ministry of Education of Czech Republic; St. Anne´s University Hospital - Translational Medicine; LQ1605
  • 2015-2018: Horizon 2020 Research Infrastructures; ELIXIR-EXCELERATE: Implementation and Early Operation of ELIXIR - the European Infrastructure for Life-Science Data; 676559
  • 2015: Horizon 2020 SME Instrument; Industrial Production of Stable Fibroblast Growth Factors for Broad Therapeutic, Research and Personal Care Applications; SEP-210181190
  • 2015-2017: Interdisciplinary Research Projects of Masaryk University; Advanced Hybrid Methods for Study of Transport Processes in Proteins and Their Application for Design of Biocatalysts; MUNI/M/1888/2014
  • 2014-2018: National Sustainability Program; The Research Centre for Toxic Compounds in the Environment; LO1214
  • 2014-2017: Grant Technological Agency of Czech Republic; Biosensor for Monitoring of Toxic Compounds in the Environment; TA04021380
  • 2014-2016: Czech-American Program CONTACT; New Concepts and Tools for Rational Design of Enzymes; LH14027
  • 2014-2015: Operational Programme Education for Competitiveness; Popularization of Science and Research in Natural Sciences and Mathematics using Potential of Masaryk University; CZ.1.07/2.3.00/45.0018
  • 2013-2015: Operational Programme Education for Competitiveness – ICRC Human Bridge – Incubator of Young Talents III; CZ.1.07/2.3.00/20.0239
  • 2013-2015: Operational Programme Education for Competitiveness – Employment of Young Scientists to Promote International Collaboration; CZ.1.07/2.3.00/30.0037
  • 2013-2015: Grant of the European Union FP7 REGPOT, Human Bridge; 316345
  • 2012-2014: Operational Programme Education for Competitiveness; Center of Experimental Biomedicine; CZ.1.07/2.3.00/20.0183
  • 2012-2016: Grant Agency of the Czech Republic; Construction of a Synthetic Metabolic Pathway for Degradation of Important Environmental Pollutant by Protein and Metabolic Engineering; P503/12/0572
  • 2012-2016: Grant Agency of the Czech Republic; Structure-Functional Relationships of Haloalkane Dehalogenases; P207/12/0775
  • 2012-2014: Grant of the European Union FP7 NewProt; An Interactive Protein Engineering Portal with Validated Software and Database Facilities; 289350
  • 2013-2014: Operational Programme Education for Competitiveness; Pre-seed PRECEDENCE; CZ.1.07/2.3.00/20.0183
  • 2011-2015: Grant of the Ministry of Education of Czech Republic; International Clinical Research Centre; CZ.1.05/1.1.00/02.0123
  • 2010-2014: Grant of the Ministry of Education of Czech Republic; Research Centre for Toxic Substances in the Environment; CZ.1.05/2.1.00/01.0001
  • 2010-2012: Grant Agency of the Czech Republic Analysis; Visualization of Protein Structures; P202/10/1435
  • 2009-2012: Grant of the Ministry of Education of Czech Republic; Mendel Centre for Education in Biology, Biomedicine and Bioinformatics; CZ.1.07/2.3.00/09.0186
  • 2009-2013: Research and Development Grant; Evolution of Substrate Specificity in Enzymes Acting on Xenobiotic Compounds; Grant Agency of the Czech Academy of Sciences; IAA401630901
  • 2008-2010: Research and Development Grant; Specific Ion Effects for Proteins in Solutions and Related Biologically Relevant Systems; Grant Agency of the Czech Republic; 203/08/0114
  • 2007-2009: Research and Development Grant; Visualization of Protein Structures; Grant Agency of the Czech Republic; 201/07/0927
  • 2006-2010: Research Centers; Center of Biocatalysis and Biotransformations; Czech Ministry of Education; LC06010
  • 2005-2011: Research Intentions; Proteins in Metabolism and during Interaction of Organisms with Environment; Czech Ministry of Education; MSM0021622413
  • 2005-2011: Research Intentions; Interactions among the Chemicals, Environment and Biological Systems and their Consequences on the Global, Regional and Local Scales; Czech Ministry of Education; MSM0021622412
  • 2004-2006: European Molecular Biology Organization and Howard Hughes Medical Institute, EMBO/HHMI Scientist; 796
  • 2004-2006: Program ERASMUS of European Union, MedNatNet - Medical Natural Sciences Network; 109757-CP-1-2003
  • 2004-2005: NATO Linkage Grant, Optical Biosensors for Contaminant Monitoring; 980504
  • 2002-2004: Program CONTACT for Czech-Japanese Collaboration; Construction of Dehalogenating Enzymes for Biotechnological Applications; Czech Ministry of Education; ME551
  • 2002-2004: Research and Development Grant; Modelling of the structure and interaction of elicitors of the fungus Phytophthora; Czech Grant Agency; 522/02/0925
  • 2001: Project Barrande; Etude du mode d'action des élicitines; protéines fongiques inductrices des mécanismes de défence des plantes; French Ministry of Education; 99063-1,2
  • 2001-2004: National Centers; Biomolecular Centre; Czech Ministry of Education; LN00A016
  • 1999-2004: Research Intentions; Structure-Function Relationships of Biomolecules and their Role in Metabolism; Czech Ministry of Education; CEZ:J07/98:143100005
  • 1999-2000: NATO Linkeage Grant; Computer Aided Engineering of Pollutants Biodegradation; NATO; MTECH.LG.974701
  • 1998-2004: Program CONTACT for Czech-Japanese Collaboration; Racional Re-design of Enzymes Involved in Degradation of Toxic Organic Pollutants; Czech Ministry of Education; ME276
  • 1997-2000: Postdoc Grant; Study of Molecular Mechanisms of Biodegradation Reactions - Construction of QSBR models and Protein Engineering of the Haloalkane Dehalogenases; Czech Grant Agency; 203/97/P149
  • 1996-2000: Research Laboratories; Laboratory of Biomolecular Structure and Dynamics; Ministry of Education; VS96095
  • 1996: Research and Development Grant; Methodology of Environmental Risk Assessment; Ministry of Environment; PPZP/340/2/96
  • 1995: Research and Development Grant; Environmental Risk Assessment; Ministry of Environment; VZ/5200/1995
  • 1993-1995: EU Project; Assessment of QSARs for Predicting Fate and Effects of Chemicals in the Environment; European Commission DGXII; EV5V-CT92-0211 and CIPD-CT93-0042
Academical Stays
  • 7-8/2011: Research Stay; Department of Biochemistry, University of Washington, Seattle, USA
  • 9/2004: EMBO Young Investigator Programme, Networking; Bioinformatics Group, International Institute of Molecular and Cell Biology, Warsaw, Poland
  • 8-9/1997: Scholarship of the Swedish Institute; Research Group for Chemometrics, Umea University, Umea, Sweden
  • 6/1997: Program to Promote International Partnerships; Department of Civil and Environmental Engineering, The University of Michigan, Ann Arbor, USA
  • 6-7/1996: FEMS Fellowship; Department of Biochemistry and Department of Biophysics, University of Groningen, Groningen, The Netherlands
  • 9-12/1994: UNESCO Fellowship MIRCEN Biotechnology; The International Institute for Biotechnology, University of Kent at Canterbury, Canterbury, UK
  • 1-4/ 1994: USIA Exchange Program Grant; Center for Environmental Biotechnology, University of Tennessee, Knoxville, USA
  • 2-7/1993: TEMPUS Student Mobility Project; Research Institute of Toxicology, University of Utrecht, Utrecht, The Netherlands
International Courses
  • 6/2008: Laboratory Management Course, European Molecular Biology Organization, Cambridge, Great Britain
  • 3/2004: Laboratory Management Course, European Molecular Biology Organization, Heidelberg, Germany
  • 9/2003: International Summer School on Computational Biology, Warsaw, Poland
  • 6/2001: International School of Structural Biology and NMR; European Commission Grant, Erice, Italy
  • 5/1999: International School of Crystallography; European Commission Grant, Erice, Italy
  • 7/1995: Course in Molecular Biotechnology; FEBS Travelling Grant, Liege, Belgium
  • 6/1995: Course on Experimental Design and Multivariate Statistics; Research Group for Chemometrics, University of Umea, Umea, Sweden
  • 9/1993: Course on Protein Modelling; European Molecular Biology Laboratory, Heidelberg, Germany
  • 3/1993: Course on Ecotoxicology; Bursary of European Environmental Research Organization, Taxel, The Netherlands
Scientific Boards
  • 2015-now: ELIXIR CZ, Czech Republic 2013-now: Institute of Computer Science, Masaryk University, Czech Republic
  • 2012-now: Faculty of Informatics, Masaryk University, Czech Republic
  • 2010-now: Centre for Toxic Compounds in the Environment, Masaryk University, Czech Republic
  • 2010-now: Centre for Applied Microbiology and Immunology in Veterinary Medicine, Research Institute of Veterinary Medicine, Czech Republic
  • 2009-now: Department of Experimental Biology, Masaryk University, Czech Republic
  • 2006-now: European Federation of Biotechnology, Section on Applied Biocatalysis, European Union
  • 2002-2006: Research Institute of Veterinary Medicine, Brno, Czech Republic
Appreciation by Science Community
  • 2015-now: member of the Editorial Board of ChemistrySelect (Wiley-VCH, Germany)
  • 2013-now: member of the Scientific Board of the Institute of Computer Science, Masaryk University, Czech Republic
  • 2009-now: member of the Editorial Board of Microbial Biotechnology, Blackwell Publishing
  • 2008-now: member of the Editorial Board of Current Opinion in Biotechnology, Elsevier
  • 2006-now: member of the Scientific Board of the European Federation of Biotechnology, Section on Applied Biocatalysis, European Union
  • 2016: The Most Highly Cited Scientist of the Year, International Centre for Clinical Research
  • 2015: Award of the Director of Department of Experimental Biology, Masaryk University
  • 2015: Long-term Excellence in Research, Masaryk University
  • 2014-2015: Senior Editor of Biotechnology Journal, Wiley-VCH
  • 2014: J. G. Mendel Prize for Excellent Result of International Significance, Masaryk University (LL Team)
  • 2013: The Learned Society of the Czech Republic regular member
  • 2005-2013: member of the Editorial Board of Biotechnology Journal, Wiley-VCH
  • 2003: European Molecular Biology Organization and Howard Hughes Medical Institute - EMBO/HHMI Scientist
  • 2003: Award of the Czech Chemical Society - Alfred Bader Prize for Bioorganic Chemistry 2002
  • 2003-2008: Editor of the FEMS Microbiology Reviews, Elsevier
  • 2003-2008: Editor of the Central European Journal of Chemistry, Central European Science Journal
  • 2002-2004: member of the Scientific Board of the Research Institute of Veterinary Medicine, Brno
  • 2001-2003: member of the Editorial Board of Environmental Toxicology and Chemistry, SETAC Press
  • 1998: Award of the Czech Society for Biochemistry and Molecular Biology - BIOTECH 1998
  • 1997: Award of the Czechoslovak Microbiological Society - Young Microbiologist
  • 1993: Award of the Dean of the Faculty of Science, Masaryk University
  • member of The Learned Society of the Czech Republic
  • member of the Czech Chemical Society
  • member of the Czechoslovak Society for Microbiology
  • member of the Czech Society for Biochemistry and Molecular Biology
Selected Publications
  • BREZOVSKÝ, Jan, Petra BABKOVÁ, Oksana DEGTJARIK, Andrea FOŘTOVÁ, Artur Wiktor GÓRA, L. IERMAK, Petra ŘEZÁČOVÁ, Pavel DVOŘÁK, Ivana KUTÁ-SMATANOVÁ, Zbyněk PROKOP, Radka CHALOUPKOVÁ a Jiří DAMBORSKÝ. Engineering a de Novo Transport Tunnel. ACS Catalysis, WASHINGTON: AMER CHEMICAL SOC, 2016, roč. 6, č. 11, s. 7597-7610. ISSN 2155-5435. doi:10.1021/acscatal.6b02081. URL info
  • AMARO, M., Jan BREZOVSKÝ, Silvia KOVÁČOVÁ, J. SYKORA, David BEDNÁŘ, Václav NĚMEC, Veronika LIŠKOVÁ, Nagendra Prasad KURUMBANG, Koen BEERENS, Radka CHALOUPKOVÁ, Kamil PARUCH, Martina HOF a Jiří DAMBORSKÝ. Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence. Journal of the American Chemical Society, 2015, roč. 137, č. 15, s. 4988-4992. ISSN 0002-7863. doi:10.1021/jacs.5b01681. URL info
  • SYKORA, J., Jan BREZOVSKÝ, Táňa KOUDELÁKOVÁ, M. LAHODA, Andrea FOŘTOVÁ, T. CHERNOVETS, Radka CHALOUPKOVÁ, Veronika ŠTĚPÁNKOVÁ, Zbyněk PROKOP, I. KUTA SMATANOVA, M. HOF a Jiří DAMBORSKÝ. Dynamics and Hydration Explain Failed Functional Transformation in Dehalogenase Design. Nature Chemical Biology, 2014, roč. 10, č. 6, s. 428-430. ISSN 1552-4450. info
  • KOUDELÁKOVÁ, Táňa, Radka CHALOUPKOVÁ, Jan BREZOVSKÝ, Zbyněk PROKOP, Eva ŠEBESTOVÁ, M. HESSELER, M. KHABIRI, M. PLEVAKA, D. KULIK, I. KUTA SMATANOVA, P. REZACOVA, R. ETTRICH, U.T. BORNSCHEUER a Jiří DAMBORSKÝ. Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel. Angewandte Chemie International Edition, Verlag Chemie, 2013, roč. 52, č. 7, s. 1959-1963. ISSN 1433-7851. doi:10.1002/anie.201206708. info
  • GORA, Artur Wiktor, Jan BREZOVSKÝ a Jiří DAMBORSKÝ. Gates of Enzymes. Chemical Reviews, 2013, roč. 113, č. 8, s. 5871-5923. ISSN 0009-2665. doi:10.1021/cr300384w. info
  • PROKOP, Zbyněk, Yukari SATO, Jan BREZOVSKÝ, Tomáš MOZGA, Radka CHALOUPKOVÁ, Táňa KOUDELÁKOVÁ, Petr JEŘÁBEK, Veronika ŠTĚPÁNKOVÁ, Rio NATSUME, J.G.E. LEEWEN, D,B. JANSSEN, J. FLORIAN, Yuji NAGATA, T. SENDA a Jiří DAMBORSKÝ. Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering. Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinhe, 2010, roč. 49, č. 35, s. 6111-6115. ISSN 1433-7851. URL info
  • JESENSKÁ, Andrea, Marta MONINCOVÁ, Táňa KOUDELÁKOVÁ, Khomaini HASAN, Radka CHALOUPKOVÁ, Zbyněk PROKOP, Z. GEERLOF a Jiří DAMBORSKÝ. Characterization of Haloalkane Dehalogenases DrbA and DmbC: Representatives of Novel Subfamily. Applied and Environmental Microbilogy, 2009, roč. 75, č. 15, s. 5157-5160. ISSN 0099-2240. URL info
  • PAVLOVÁ, Martina, Martin KLVAŇA, Radka CHALOUPKOVÁ, Pavel BANÁŠ, Michal OTYEPKA, R. WADE, Yuji NAGATA a Jiří DAMBORSKÝ. Redesigning Dehalogenase Access Tunnels as a Strategy for Degrading an Anthropogenic Substrate. NATURE CHEMICAL BIOLOGY, 2009, roč. 0000, č. 5, s. 727-733. ISSN 1552-4450. URL info

2017/07/19