Laboratories of Dr. Konstantinos Tripsianes (CEITEC MU) and Prof. Vítězslav Bryja (Faculty of Science MU) are looking for new colleagues: (i) Research technician workload: 40 hours per week work tasks: a) general molecular biology tasks: DNA and protein analysis, transformation, … Read More
Abstract: Casein kinases 1 (CK1) are key signaling molecules that have emerged recently as attractive therapeutic targets in particular for the treatment of hematological malignancies. Herein, we report the identification of a new class of potent and highly selective inhibitors … Read More
Abstract: The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression. While the research in immunopathology mostly employed powerful indirect methods such as flow cytometry, these cells were rarely observed … Read More
Abstract: Spontaneous bleeds are a leading cause of death in the pediatric JAG1-related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vascular defects, and whether … Read More
Abstract: Over the past decades an extensive effort has been made to provide a more comprehensive understanding of Wnt signaling, yet many regulatory and structural aspects remain elusive. Among these, the ability of Dishevelled (DVL) protein to relocalize at the … Read More
Abstract: The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the … Read More
Abstract: Luciferase reporter assays represent a simple and sensitive experimental system in cell and molecular biology to study multiple biological processes. However, the application of these assays is often limited by the costs of conventional luminometer instruments and the versatility … Read More
Abstract: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic … Read More
OFIŽ: novinky pro únor 2022 Milí studenti, kolegové a přátelé, posíláme novinky a zajímavosti pro měsíc únor. Když byste měli novinku, akci nebo zajímavost, kterou byste chtěli do příštího newslettteru přidat, pište na lus@sci.muni.cz. Pozvánky Pozvánka na PhD Workshop Srdečně Vás zveme … Read More
Zajímáte se o problematiku autorského práva? Na webináři se dozvíte více o spoluautorství, výjimkách a omezeních, výkonu práv i licencích. Probereme také téma zaměstnaneckého a školního díla a vymáhání práv. Webinářem vás provede specialista na autorské právo Matěj Myška. Registrujte … Read More