A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response

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The inhalation of metal (including lead) nanoparticles poses a real health issue to people and animals living in polluted and/or industrial areas. In this study, we exposed mice to lead(II) nitrate nanoparticles [Pb(NO3)2 NPs], which represent a highly soluble form … Read More

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

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Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders often affecting skeletal development. This includes Jeune syndrome or asphyxiating thoracic dystrophy (ATD), an autosomal recessive skeletal disorder. Unraveling the responsible molecular pathology helps illuminate mechanisms responsible … Read More

Differences in the growth rate and immune strategies of farmed and wild mallard populations

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Individuals reared in captivity are exposed to distinct selection pressures and evolutionary processes causing genetic and phenotypic divergence from wild populations. Consequently, restocking with farmed individuals may represent a considerable risk for the fitness of free-living populations. Supportive breeding on … Read More

Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon

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Secondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary … Read More

Psychopatologické poruchy v kontextu (chronické) lymeské borreliózy

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Publikovaná data ukazují, že infekce bakteriemi komplexu Borrelia burgdorferi sensu lato, původci lymeské borreliózy, může u pacientů vyvolat psychické potíže a neuropsychiatrické symptomy. Bylo zjištěno, že počet psychopatologických poruch roste v souvislosti s delším obdobím infekce a že většina takto … Read More

Heptabladed β‐propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O‐methylated sugars and influence the host immune system

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O‐methylation is an unusual sugar modification with a function that is not fully understood. Given its occurrence and recognition by lectins involved in the immune response, methylated sugars were proposed to represent a conserved pathogen‐associated molecular pattern. We describe the … Read More

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