An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice
Abstract: Achondroplasia is the most prevalent genetic form of dwarfism in humans and is caused by activating mutations in FGFR3 tyrosine kinase. The clinical need for a safe and effective inhibitor of FGFR3 is unmet, leaving achondroplasia currently incurable. Here, … Read More