Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

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Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development, we employed gene trap knock-out … Read More

The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype

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Autoři: Eva Krkavcová, Jakub Kreisinger, Ludmila Hyánková, Pavel Hyršl, Veronika Javůrková Časopis: Open Biology ABSTRAKT Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is … Read More

Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro

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Autoři: Barbora Šafránková, Martina Hermannová, Kristina Nešporová, Vladimír Velebný, and Lukáš Kubala Publikováno v: International Journal of Biological Macromolecules Abstrakt Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells … Read More

Puncture vs. reflex bleeding: Haemolymph composition reveals significant differences among ladybird species (Coleoptera: Coccinellidae), but not between sampling methods

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Michal KNAPP1, Pavel DOBEŠ2, Michal ŘEŘICHA1, Pavel HYRŠL2 1 Department of Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic; e-mails: knapp@fzp.czu.cz, rericham@fzp.czu.cz 2 Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty … Read More

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