Biomolekulární chemie a bioinformatika

Podat přihlášku

Přijímací řízení do doktorských programů - akad.rok 2021/2022 (zahájení: podzim 2021)
Termín podání přihlášky do půlnoci 30. 4. 2021

Co se naučíte

Program Biomolekulární chemie a bioinformatika otevírá studentům cestu k hlubokým znalostem o stavbě biologicky významných bio(makro)molekul (proteinů, nukleových kyselin, oligosacharidů a pod.) a o vztahu mezi jejich strukturou a biologickou funkcí. Studenti jsou školeni v metodách získávání a aplikace poznatků o struktuře a funkci bio(makro)molekul. Technické zázemí umožní studentům běžně pro svou práci využívat nejmodernější metody experimentální (nukleární magnetická rezonance, rentgenová krystalografie, kryo-elektronová mikroskopie, moderní metody studia biomolekulárních interakcí, metody molekulární biologie) a výpočetní (kvantová chemie, molekulová mechanika a dynamika). Důraz je kladen na samostatnou práci studentů v rámci řešených projektů včetně schopnosti komunikovat a prezentovat výsledky v anglickém jazyce. Studenti se také naučí využívat informace dostupné v literatuře a elektronických databázích. Nabídka specializovaných přednášek umožní studentům prohloubení teoretických znalostí.

Studium pokrývá následující výzkumné oblasti:

Výpočetní chemie a chemoinformatika

Strukturní bioinformatika

Strukturní analýza pomocí nukleární magnetické rezonance, rentgenové difrakce a kryo elektronové mikroskopie

Glykobiochemie

Interakce proteinů s buněčnou membránou

Strukturní virologie

Struktura a dynamika nukleových kyselin

Strukturní biologie genové regulace

Nekódující genom

Kontrola kvality RNA

Rekombinace a oprava DNA

Analýza sekvencí DNA

Sekvenování nové generace

Zaměření studijního programu je multidisciplinární a naučí studenty kombinovat poznatky různých oborů.

Chcete vědět víc?

http://ncbr.muni.cz

Uplatnění absolventů

Cílem studijního programu je připravit špičkové odborníky, kteří budou nejen specialisty s detailní znalostí určité techniky, ale také tvůrčími pracovníky s širokým rozhledem v oblasti biomolekulární chemie a bioinformatiky a s dobrými teoretickými základy. Ačkoli bude absolvent formován především pro akademickou dráhu, bude i odborníkem připraveným uplatnit se v komerčním prostředí zejména v biochemickém a farmaceutickém výzkumu, v práci s biologicky orientovanými databázemi a v oborech využívající pokročilé metody výpočetní chemie a bioinformatiky. Studijní pobyty a zahraniční kontakty umožní absolventovi nalézt uplatnění i na špičkových zahraničních pracovištích.

Podmínky přijetí

K doktorskému studiu Biomolekulární chemie a bioinformatika jsou přijímáni absolventi magisterského vysokoškolského studia stejného nebo příbuzného oboru. Předchozí praxe není podmínkou přijetí. Uchazeč by měl na základě diplomové práce případně vlastních publikací prokázat předpoklady tvořivé práce v oboru. Kromě toho by měl mít základní znalosti z biochemie a strukturní biochemie. Požaduje se schopnost komunikace v anglickém jazyce na úrovni překladu populárně naučného článku z angličtiny do češtiny, napsání krátkého anglického souhrnu a obecné diskuse na témata související zejména s vlastním životopisem, vysokými školami a výzkumnou činností. Při přijímacím řízení se hodnotí odborné znalosti (max. 100 bodů) a jazykové znalosti (max. 100 bodů) Pro přijetí musí uchazeč získat alespoň 160 bodů.


Termíny

1. 1. – 30. 4. 2021

Termín pro podání přihlášek

Podat přihlášku

Školitelé a výzkumná zaměření dizertačních prací

Školitelé

Součástí přihlášky je jméno předpokládaného školitele. Školitele si vyhledejte podle profilového zaměření ze seznamu školitelů a konzultujte s ním jeho potenciální školitelství a návrh projektu.

Výzkumná zaměření dizertačních prací

Jednooborové studium

Analýza proteinových strukturních rodin

Školitel: doc. RNDr. Radka Svobodová, Ph.D.

V současné době máme k dispozici nadkritické množství informací ohledně proteinových strukturních rodin. Konkrétně, pro většinu rodin známe stovky struktur jejích zástupců, přičemž tyto struktury pocházejí z různých organismů, některé z nich váží rozličné ligandy a mnohé obsahují různorodé mutace. Tyto informace umožňují analýzu „anatomie“ daných proteinových rodin. Například studium elementů sekundární struktury (šroubovic a skládaných listů), jejich vzájemného uspořádání, konzervovanosti a určování, které z těchto elementů jsou pro danou proteinovou rodinu klíčové a které se vyskytují jen raritně. Dále pak zkoumání proteinových tunelů a pórů, jejich charakteristik a četnosti jejich výskytu u jednotlivých zástupců proteinové rodiny. V rámci laboratoře LCC jsou vyvíjeny softwarové nástroje pro realizaci výše uvedených analýz, např. software MOLE, LiteMol, SecStrAnalyzer. Hlavním cílem disertační práce je zaměřit se na několik konkrétních biologicky významných proteinových rodin (např. cytochromy, poriny, dehalogenázy, proapoptotické proteiny) a provést jejich detailní analýzu. Dalším cílem je spolupráce při vývoji uvedených softwarových nástrojů.

Poznámky

Vypsáno pro přihlášení studentky Jany Porubské.

Identifikace faktorů ovlivňujících selektivitu/účinost léčiv v prostředí živých buněk

Školitel: doc. Mgr. Lukáš Trantírek, Ph.D.

Objectives: The research aims to develop and apply novel approaches of in-cell NMR spectroscopy to rational drug design.

Focus: Doctoral research projects focus on the characterization of structures and interactions of selected protein/nucleic acid-based drug targets in the complex intracellular environment. Students will acquire experience with: UV/CD/NMR spectroscopy, chemical modifications of nucleic acids, DNA cloning, human cell culture manipulations, and/or work with alternative biological models (Xenopus laevis).

Examples of potential student doctoral thesis:
A] Early assessment of potency of candidate drugs targeting G-quadruplex nucleic acids.
B] Validation of drug target structure in pathogens (bacteria) and cancer (human) cells.

Representative publications"
1: Broft P, Dzatko S, Krafcikova M, Wacker A, Hänsel-Hertsch R, Dötsch V,
Trantirek L, Schwalbe H. In-Cell NMR Spectroscopy of Functional Riboswitch
Aptamers in Eukaryotic Cells. Angew Chem Int Ed Engl. 2021 Jan 11;60(2):865-872. 2: Krafcikova M, Dzatko S, Caron C, Granzhan A, Fiala R, Loja T, Teulade-Fichou
MP, Fessl T, Hänsel-Hertsch R, Mergny JL, Foldynova-Trantirkova S, Trantirek L.
Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy.
J Am Chem Soc. 2019 Aug 28;141(34):13281-13285. 3: Dzatko S, Krafcikova M, Hänsel-Hertsch R, Fessl T, Fiala R, Loja T, Krafcik
D, Mergny JL, Foldynova-Trantirkova S, Trantirek L. Evaluation of the Stability
of DNA i-Motifs in the Nuclei of Living Mammalian Cells. Angew Chem Int Ed Engl.
2018 Feb 19;57(8):2165-2169.

Please note: Before initiating the formal application process to doctoral studies, all interested candidates should contact doc. Trantirek (lukas.trantirek@ceitec.muni.cz) for an informal discussion.

Inhibition of DNA repair nucleases – from biological probe to cancer therapy

Školitel: doc. Mgr. Lumír Krejčí, Ph.D.

We invite applications for a PhD studentship from applicants with an enthusiastic interest in molecular biology and biochemistry. The successful candidate will work under the supervision of Dr. Krejčí to identify and characterize novel inhibitors of DNA repair nucleases, their mechanisms of action and therapeutic implications.

The PhD position candidate should hold or be about to complete a Masters degree in molecular biology, biochemistry or similar field. The applicant is also expected to demonstrate essential training in a range of molecular biology techniques relevant to basic research, should be well-organised, motivated and passionate about pursuing a career in biomedical research.

We offer fully funded positions with competitive salary in a well established laboratory. The lab hosts international team members, has a strong publication track record and international collaborations. The offered projects contribute to a rapidly advancing, very competitive field. The successful candidate can start immediately.

Mechanismus antimikrobiálních peptidů

Školitel: doc. RNDr. Robert Vácha, PhD.

OBJECTIVES: The aim is to elucidate the relationship between molecular properties of amphiphilic peptides and their ability to translocate and form transmembrane pores in membranes with various lipid compositions. The obtained understanding will be used for the development of new antimicrobial peptides, which can serve as a new type of antibiotic drugs.



DESCRIPTION: Antibiotic-resistant bacteria cause more than 700 000 deaths per year, and the forecast is 10 million per year in 2050. Moreover, emerging strains of bacteria resistant to all available antibiotics may lead to a global post-antibiotic era. Because of this threat, the WHO and the UN are encouraging the research and development of new treatments. Antimicrobial peptides are promising candidates for such new treatments. We will study the molecular mechanism of action of antimicrobial peptides and determine the critical peptide properties required for membrane disruption via the formation of transmembrane pores and spontaneous peptide translocation across membranes. Based on the obtained insight, we will design new peptides and test their abilities. The most effective peptides will be evaluated for antimicrobial activity and human cell toxicity using growth inhibition and hemolytic assays, respectively. Student(s) will master tools of computer simulations, in particular, molecular dynamics techniques and methods to calculate free energies. Moreover, he/she will learn the advantages and disadvantages of various protein and membrane parameterizations, including all-atom and coarse-grained models. The simulations will be complemented by in vitro experiments using fluorescent techniques.



EXAMPLES of potential projects: * Antimicrobial peptides and formation of membrane pores * Synergistic mechanisms between antimicrobial peptides * Membrane disruption by antimicrobial peptides in non-equilibrium conditions



MORE INFORMATION about the group: vacha.ceitec.cz



PLEASE NOTE: before the formal application process, all interested candidates should contact Robert Vacha (robert.vacha@mail.muni.cz).
Peptide selectivity for lipid membranes

Školitel: doc. RNDr. Robert Vácha, PhD.

Peptidová/proteinová afinita k membránám je závislá na konkrétní sekvenci a membránovém složení. Bohužel porozumění tohoto komplexního vztahu nám dosud chybí. Cílem tohoto projektu odhalit tento vztah a využít ho k vývoji nových antimikrobiálních peptidů, biomarkerů a senzorů.

Student získá znalosti v oblasti fluorescence, lipidových váčků, QCM.

Protein Structure and Dynamics

Školitel: prof. Mgr. Lukáš Žídek, Ph.D.

The research goal is investigation of structure, dynamics, and biologically relevant properties of proteins, using NMR spectroscopy and other high-resolution approaches. Currently, our group is mostly interested in studies of molecular motions using NMR relaxation and relaxation dispersion; in studies of protein disorder using NMR approaches providing sufficient resolution (usually based on non-uniformly sampled high-dimensional spectra); and in studies of interactions of intrinsically disordered proteins with their binding partners (using NMR, cryo-EM, and biophysical methods). The systems currently studied in the laboratory include bacterial RNA polymerases and microtubule associated proteins.

We are inetrested structure and dynamics of well-ordered and domains of subunits and sigma factors of RNA polymerase from B. subtilis, characterization of structural features and dynamics of disordered domain, and in importance of electrostatic interactions for structural properties and biological function of the protein. Currently we extend our interest to mycobacterial RNA polymerase.

Microtubule associated protein 2c (MAP2c) is a key factor regulating microtubule dynamics in developing brain neurons, and an example of an intrinsically disordered proteins with an important physiological function and detectable structure-function relationship. The first goal is to study MAP2c in a natural complexity and by methods providing atomic resolution. Such methods include paramagnetic relaxation interference, to detect and describe transient local structures of MAP2c important for its function, and real-time NMR, to monitor kinetics of MAP2c phosphorylation by relevant kinases of different signalling pathways. The second goal is to characterize interactions of MAP2c with biologically important binding partners, especially with isoforms and a monomeric form of regulatory protein 14-3-3. The third goal is to test the effect of cellular environment on MAP2c by recording NMR spectra at near-to-native conditions (in cells and/or cell lysates) and/or by performing cryo-electron tomography on monolayered neurons.

EXAMPLES OF POTENTIAL PHD TOPICS:
  • Interactions underlying physiological function of Microtubule Associated Protein 2c
  • Structure, dynamics and interactions of bacterial RNA polymerase subunits and sigma factors
Proteinová přitažlivost a selektivita pro buněčné membrány

Školitel: doc. RNDr. Robert Vácha, PhD.

OBJECTIVES: The aim is to elucidate the relationship between protein sequence and preferred composition and curvature of human membranes,i.e., find peptide motifs that are selective to specific membranes in cells (plasma membrane, endoplasmic reticulum, Golgi apparatus, mitochondria, etc.). The obtained understanding will be used for the development of new protein biomarkers, sensors, scaffolds, and drugs.



DESCRIPTION: The control of biological membrane shape and composition is vital to eukaryotic life. Despite a continuous exchange of material, organelles maintain a precise combination and organization of membrane lipids, which is crucial for their function and the recruitment of many peripheral proteins. Membrane shape thus enables the cell to organize proteins and their functions in space and time, without which serious diseases can occur. Moreover, membrane curvature and lipid content can be specific to cancer cells, bacteria, and enveloped virus coatings, which could be utilized for selective targeting. We will develop a new method, using which we will elucidate the relationship between the protein sequence and the preferred membrane. The relationship will lay the foundations for the design of new protein motifs sensitive to membranes with a specific curvature and composition. Student(s) will master tools of computer simulations, in particular, molecular dynamics techniques and methods to calculate free energies. Moreover, he/she will learn the advantages and disadvantages of various protein and membrane parameterizations, including all-atom and coarse-grained models.



EXAMPLES of potential projects: * Determination of helical motifs for specific membrane compositions * Development of implicit membrane model for fast determination of protein-membrane affinity * Helical peptides and their sensitivity for membrane curvature



MORE INFORMATION: vacha.ceitec.cz



PLEASE NOTE: before the formal application process, all interested candidates should contact Robert Vacha (robert.vacha@mail.muni.cz).
RNA as a drug target

Školitel: Mgr. PharmDr. Peter Lukavsky, Dr. rer. nat.

RNA is an attractive drug target with enormous potential for future treatment of systemic and cancer-related pathologies. Yet, most of the currently applied and developed small molecule therapeutics for cancer and systemic diseases target proteins. Interestingly, from 20000 human protein-coding genes (1.5% of the human genome) only 2000-3000 genes are considered to be disease-related. In this context, small molecule drug therapies target less than 700 genes which represents less than 0.05% of the genome. While the portion of protein-coding information in the genome is minor, the ENCODE consortium has proposed that more than 75% of our genome is transcribed into RNAs. This also includes large non-coding regions of mRNAs, namely 3’UTRs which contain many regulatory elements important for spatio-temporal regulation of gene expression, such as translational control, RNA transport and localization and mRNA decay. We propose to target non-coding mRNA elements with small molecules to alter gene expression. We will focus on cancer-related genes, where protein targets often lack druggable elements and therefore targeting them on the mRNA level is an attractive alternative. Our research aims to identify functional mRNA motifs that can bind small molecules and to reveal common small molecule scaffolds which interact with similar 3D RNA structures and thus form a basis for rational lead optimization.

We are looking for highly motivated PhD candidates with background in biochemistry and biophysics who share our fascination for RNAs regulating gene expression.

PLEASE NOTE: before initiating the formal application process to doctoral studies, all interested candidates are required to contact the supervisor.

https://www.ceitec.eu/rna-based-regulation-of-gene-expression-peter-lukavsky

RNA Quality Control

Školitel: doc. Mgr. Štěpánka Vaňáčová, Ph.D.

The internal and external RNA modifications play crucial roles in a number of essential processes of eukaryotic organisms. They regulate the production of germ cells, cellular differentiation, response to stress, and defects in this pathway have been linked to a number of human diseases.

The aim of PhD projects is to study in details on how specific terminal RNA modifications regulate cellular differentiation and to study the protein-protein interactions of factors involved in the regulation of adenosine methylation (m6A) in coding and noncoding RNAs.

Prospective student should ideally have done masters in molecular biology/biochemistry and have laboratory experience in nucleic acids and/or protein purification and analysis. The most highly valued feature will, however, be excitement for science and a strong drive in tackling important biological questions.

EXAMPLES OF POTENTIAL PHD TOPICS:

  • The role of posttranscriptional RNA modifications in cell differentiation
  • The role of protein-protein interactions in the dynamics of m6A RNA modification

PLEASE NOTE: before initiating the formal application process to doctoral studies, all interested candidates are required to contact the supervisor

MORE INFORMATION: https://www.ceitec.eu/rna-quality-control-stepanka-vanacov

Structural biology of WNT signalling

Školitel: Konstantinos Tripsianes, Ph.D.

We apply structural biology methods in order to gain a mechanistic view of CK1ε action in the Wnt signalling pathways. CK1ε represents an attractive therapeutic target but currently two key steps in the CK1ε-mediated Wnt signal transduction are unclear: how CK1ε gets activated and/or engages target proteins in response to Wnt signal and how CK1ε phosphorylates its key substrate Dishevelled (DVL).

Our preliminary data suggest that we can efficiently apply methods of integrated structural biology to (i) probe the DVL conformational landscape using in vitro and in vivo FRET sensors coupled to SAXS and CryoEM, (ii) understand the (auto)phosphorylation regulatory mechanisms of CK1ε, (iii) analyse by NMR the functional consequences of DVL phosphorylation and (iv) monitor DVL phosphorylation by real-time NMR under controlled cellular conditions. The position is part of a multidisciplinary project that combines (i) cellular and molecular biology, (ii) proteomic analysis, (iii) biochemistry and structural biology, and received generous funding in a very competitive grant scheme.

Keywords: CK1ε, WNT, DVL phosphorylation, SAXS, cryo-EM, cryo-electron microscopy, real-time NMR

Contact:
Kostas Tripsianes, PhD | CEITEC - Central European Institute of Technology | Masaryk University | Kamenice 5/A35/1S081, CZ-62500 Brno | phone: 00420 549 49 6607

Structure of non-canonical forms of DNA

Školitel: prof. RNDr. Radek Marek, Ph.D.

DNA forms not only the canonical duplex but also various non-canonical structures such as triplex, G-quadruplex, and i-motif. The are many external factors that influence folding and stability of the individual forms. Further, DNA structure can be affected by attachment of various artificial covalent or noncovalent ligands.

Our investigations are focused on detailed structural characterization of short purine oligonucleotides clipped by proper sequential blocks. For this purpose, modern NMR experiments combined with MD simulations are employed. The effect of modification of selected nucleotide on the structural properties of designed models is characterized to gain deeper understanding of key noncovalent interactions that contribute to the DNA folding.

Examples of PhD topics:
a) Structure of parallel forms of nucleic acids studied by NMR spectroscopy and molecular modelling
b) Designing modified DNA fragments

More information:
radek.marek@ceitec.muni.cz
jan.novotny@ceitec.muni.cz

Poznámky

Note: All candidates should contact R. Marek for informal discussion before initiating the formal application process.

Strukturní dynamika, funkce a evoluce RNA a DNA. Od vzniku života až po moderní biochemické procesy a strukturni biologii.

Školitel: prof. RNDr. Jiří Šponer, DrSc.

Our scientific goal is understanding of the most basic principles of structural dynamics, function and evolution of DNA and RNA.

To achieve our goal, we use a wide portfolio of theoretical/computational approaches. Our research is closely related to experiments, mostly via extensive collaborations, though in the prebiotic chemistry we have in house experiments. We offer thesis essentially on any topic that is currently active in the laboratory. You can get the most up-to-date idea about our current research from the WOS or SCOPUS databases, where you can find all our publications (Sponer, J.), see all our collaborators, etc. The laboratory is located at the Institute of Biophysics, Czech Academy of Sciences, Kralovopolska 135, Brno, where we have a powerfull and regularly upgraded set of high-perfomance computer clusters dedicated exclusively to our group

Our methods are:
  • Classical Molecular Dynamics (MD) simulations. Besides standard simulations, we have years of experience in using all classes of enhanced-sampling techniques. We play also a prominent role in development of DNA/RNA simulation force fields and our versions are used world-wide
  • Quantum-chemical (QM) method. We are using a wide spectrum of methods, ranging from ultra-accurate computations of small model systems, through large-scale QM studies on biomolecular building blocks with hundreds of atoms up to sophisticated methods that are used in studies of excited states and photochemistry; the later technique is especially relevant to study the origin of life chemistry under UV light. Again, please see the papers we have published in last years.
  • Hybrid quantum-classical (QM/MM) methods, quantum molecular dynamics
  • Structural bioinformatics
Specific experiments are possible in the field of prebiotic chemistry in collaborating laboratories. Modern computations are extensively combined with many experimental techniques (NMR, X-Ray, high-energy lasers, biochemical techniques) mostly via numerous collaborations. We collaborate with 30 foreign and Czech laboratories. We publish about 20 papers annually and belong to the most cited Czech research groups. We currently work in several mutually interrelated research areas.
  • RNA structural dynamics, folding and catalysis
  • Protein-RNA (or DNA) complexes. We try to go beyond the ensemble-averaged picture of experimental methods in order to understand how rarely accessed dynamical conformations invisible to experiments allow to separate affinity for reactivity or selectivity.
  • DNA, with focus on G-quadruplexes, specifically advanced studies of quadruplex folding mechanisms
  • Diverse types of quantum-chemical studies on nucleic acids systems
  • Origin of life (prebiotic chemistry), i.e., creation of the simplest chemical life on our planet (or anywhere else in the Universe), with a specific attention paid to the formamide pathway to template-free synthesis of the first RNA molecules. This specific project includes also in house experimental research.

Besides studies of specific systems, we are also involved extensively in method testing/development, mainly in the field of parametrization of molecular mechanical force fields for DNA

NOTE: before initiating the formal application process to doctoral studies, all interested candidates are required to contact Prof. Jiri Sponer (sponer@ncbr.muni.cz) for an informal discussion.

Laboratory web page https://www.ibp.cz/en/research/departments/structure-and-dynamics-of-nucleic-acids/info-about-the-department

List of publications https://www.ibp.cz/en/research/departments/structure-and-dynamics-of-nucleic-acids/publications
Studium molekulární podstaty opravy DNA a její význam u nádorových onemocnění

Školitel: doc. Mgr. Lumír Krejčí, Ph.D.

Naše laboratoř se zaměřuje na studium molekulární podstaty zhoubných onemocnění, které souvisí s rekombinací a opravou poškozené DNA. DNA obsažená v lidské buňce je neustále poškozována vnějšími i vnitřními vlivy (radiace, UV záření ale i chybná replikace apod.) Různých poškození nebo zlomů v DNA je až půl milionu za den. Poškozená DNA zpomaluje nebo dokonce zastaví replikační vidlici a vede k nestabilitě genomu a je asociována se vznikem celé řady onemocnění, včetně rakoviny. Jedním z mechanismů, který zaručuje bezchybnou opravu poškozené DNA a její replikaci je homologní rekombinace. Experimentální práce zahrnuje širokou škálu molekulárně-biologických přístupů vč. amplifikace a klonování DNA, expresi proteinů a jejich purifikace, studium proteinových interakcí a další charakterizace pomocí biochemických, molekulárně biologických, biofyzikálních, strukturálních, buněčně biologických a genetických metod.

Změny ve struktuře proteinů a jejich tvorby komplexů spojených s neurodegenerativními nemocemi.

Školitel: RNDr. Mgr. Jozef Hritz, Ph.D.

BACKGROUND: Several neurodegenerative diseases are associated with the formation of fibrous protein aggregates. The fibrillization of amyloid beta peptide into amyloid plaques and the agregation of hyperphosphorylated tau protein into neurofibrillar tangles are main neuropatological signs of Alzheimer disease. Studying of how different factors influence the formation of biomolecular complexes is the key for understanding underlying molecular mechanism of neurodegerative processes. The described activities are part of international research projects allowing to spend the part of PhD study at the collaborative groups in Europe or North and South America and to learn specific research techniques, there.

OBJECTIVES: The research aims to elucidate molecular mechanisms of conformational changes leading to the modified potential of biomolecular complex formation. Interdisciplinary approach combining computational biophysical chemistry, structural biology, bioinformatics and biophysical interaction techniques will be applied.

FOCUS: Doctoral research projects focus on the monitoring of post-translational modification of studied proteins, their interaction with adaptor proteins and induced conformational changes. Students benefit from outstanding research facilities of CEITEC-MU that include cryoEM tomography, NMR, AFM, and biophysical interaction methods.

EXAMPLES of potential student doctoral projects:

  • Are Tau fibrils induced by phosphorylation and the interaction with 14-3-3 proteins relevant for Alzheimer disease?
  • A Tau conformational changes induced by phosphorylation and 14-3-3 proteins relevant in neurodegenerative diseases
  • Oligomerization states within the 14-3-3 protein family
  • Computational prediction of biomolecular complexes and their statibities

MORE INFORMATION: jozef.hritz@ceitec.muni.cz

PLEASE NOTE: before initiating the formal application process to doctoral studies, all interested candidates are required to contact Jozef Hritz (jozef.hritz@ceitec.muni.cz) for informal discussion.

Informace o studiu

Zajišťuje Přírodovědecká fakulta
Typ studia doktorský
Forma prezenční ano
kombinovaná ano
Možnosti studia jednooborově ano
jednooborově se specializací ne
v kombinaci s jiným programem ne
Doba studia 4 roky
Vyučovací jazyk čeština
Oborová rada a oborové komise

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