Molecular and Cell Biology and Genetics

This doctoral study programme is organized by the Faculty of Science in English and the studies are subject to tuition. There is an alternative option for the international applicants to be accepted in the free programme administered in Czech with the possibility of receiving a scholarship. The study language of the programme is still English (Czech is the administrative language). Before officially applying, please contact us at admission@sci.muni.cz to find all the necessary information related to the scholarship and see our FAQ’s.

Podat přihlášku

International applicants for doctoral study (Czech and Slovak Republics applicants NOT included)
Termín podání přihlášky do půlnoci 15. 12. 2024.

Co se naučíte

The program is a product of the fusion of former independent Molecular and Cellular Biology with General and Molecular Genetics. We propose the fusion to reflect modern holistic approaches dominating in both fields that converge them to close proximity and bring benefits to both of them. The aim of the program is to provide excellent scientific education in the field of molecular and cell biology and genetics. The graduates thus should be proficient to accomplish research of the nature of living phenomena on molecular, cellular, tissue and organismal levels. To achieve this aim, students are systematically guided to advance their theoretical knowledge in the field and master practical skills in applications of modern methods of molecular and cellular biology, genetics and other related fields. The key themes include the study of genes and genomes and their expression in microorganisms, plants, animals and humans. Special attention is paid to their relations to pathological conditions. Research performed on microorganisms is focused preferentially on molecular diagnosis and genomics of selected pathogenic and clinically significant bacterial strains and their interactions with bacteriophages. Research on plants is concentrated mainly on the study of genes of model plants and plants used in agriculture. In animals and humans, research is focused on the genetical structure of populations, molecular diagnosis of prenatal and postnatal pathogenic situations, genetics of tumours, the study of signalling processes connected with the regulation of proliferation, differentiation and programmed cell death in tumour cells and detection of genetical factors associated with certain polygenic diseases. Students are free to perform independent research in well-equipped laboratories and experienced supervisors are nominated to guide them in this effort. Students are continuously confronted with progress in the field by discussions in regular laboratory meetings, institutional seminars or conferences. Successful conference presentations or published articles are awarded by a special stipend.

„Windows of the living cell universe wide-opened.“

Praxe

The students who are interested in applied research can collaborate with companies as Repromeda (assisted reproduction), MB Pharma (devising phage preparations) or to participate in grant projects funded by TACR leading to applied outcomes. We aim to further support contractual research with applied potential, search for suitable partners and provide them with option to collaborate with students interested in this kind of research.

Chcete vědět víc?

Additional information can be found in following addresses:

http://www.sci.muni.cz/cz/DoktorskeStudium/Prehled-programu-a-oboru

http://www.sci.muni.cz/cz/UEB

Uplatnění absolventů

Graduates find positions in various research institutes, universities, hospitals and other medical facilities and laboratories oriented to virology, microbiology, genetics, biochemistry, immunology, pharmacology, pathology, etc. They are ready to perform independent research, draft scientific projects, create grant applications, experimental work itself, including rigorous interpretations of results and presentations in oral as well as written forms. They are also educated to act as teachers. Graduates from this program are sought-after by employers and many of them currently work on positions of leading researchers, university teachers, top managers and directors in various research and education institutions in the Czech Republic. Many graduates leaves for postdoctoral stays abroad, especially to westeuropean countries, USA, Canada, Japan, Australia. They often become highly-appreciated members of research teams there.

Podmínky přijetí

Admission procedure
The admission interview is usually in an online form and consists of two parts:
1) expert interview – checking expertise background and motivation (max. 100 points),
2) Language part – check of communication skills in English, interview and expert discussion is in English (max. 100 points)

More information about admission process for international applicants in general can be found in the section Admission Process.

Date of the entrance exam
The applicants will receive information about the entrance exam by e-mail usually at least 10 days before the exam.
Please, always check your e-mails, including spam folders.

Conditions of admission
To be admitted, a candidate must obtain a total of 70 out of 100 points in the expert knowledge part and 60 out of 100 points in the language part.
Successful applicants are informed of their acceptance by e-mail and subsequently receive an invitation to the enrolment.

Programme capacity
The capacity of a given programme is not fixed; students are admitted based on a decision by the Doctoral Board after assessing their aptitude for study and motivation.

Termíny

2. 1. – 15. 12. 2024

Termín pro podání přihlášek

Podat přihlášku

Výzkumná zaměření dizertačních prací

Jednooborové studium

Identifikace nových molekulárních cílů a prognostických markerů u neuroblastomu řízená transkriptomikou na úrovni jednotlivých buněk
Školitel: RNDr. Jan Škoda, Ph.D.

Neuroblastoma is the most common and highly lethal extracranial pediatric solid tumor, characterized by extensive intratumor and interpatient heterogeneity that dictates its clinical manifestation and complicates its management. Currently, about one in ten low- and intermediate-risk patients is misclassified and eventually dies from progressive disease, while available therapies still fail in half of the high-risk neuroblastoma cases. Neuroblastoma arises anywhere along the sympathetic nervous system, probably from neural crest cell (NCC)-derived sympathoadrenal progenitors. Recent single-cell transcriptomics studies of our collaborators shed new light on NCC differentiation and provided unprecedented insights into differentiation trajectories and cellular transition states during normal sympathoadrenal development. As suggested by our published and preliminary results, translating this updated understanding of the sympathoadrenal development into neuroblastoma research might hold the key for unraveling neuroblastoma heterogeneity. The main aim of this thesis is to explore the utility of single-cell transcriptomics data for identification of clinically useful therapeutic targets and markers that could be streamlined into improved neuroblastoma treatment protocols.
Supported by the Ministry of Health of the Czech Republic, project NW24-07-00017.

Poznámky

PLEASE NOTE: Before initiating the formal application process to doctoral studies, interested candidates are required to contact Dr. Jan Škoda for informal discussion.

Školitel

RNDr. Jan Škoda, Ph.D.

Molekulární patologie a personalizovaný přístup v onkologii
Školitel: RNDr. Ing. Ondřej Bonczek, Ph.D.

Řada genových mutací, které způsobují vývojové abnormality, např. orofaciální vady, jsou sdílené s onkologickými onemocněními a jsou zodpovědné rovněž za indukci karcinogeneze. Nicméně současné znalosti o asociacích sdílených molekulárních charakteristik mezi orofaciálními anomáliemi a karcinogenezí jsou minimální. Cílem práce bude zaměřit se na současný výskyt orofaciálních abnormalit a nádorových onemocnění. Dále zjistit, zda by bylo možné využít znalosti sdílené asociace genů a nalezených genetických variant např. k cílenému časnému záchytu rakoviny. Metodicky se bude dizertační práce zabývat především přípravou exomových a multigenových sekvenačních knihoven, eventuálně dalšími metodami analýzy genetických změn. Mimo včasného screeningu rakoviny se bude dizertační práce zabývat zajímavými genomovými změnami, které jsou detekované při molekulárním profilování nádorů v rámci rutinních prediktivních vyšetření. Jedná se např. o sekundární reverzní mutace, varianty identifikované v Kozakově sekvenci, varianty v oblastech sestřihu exonů apod. Obvykle však nejsou tyto aberace hlouběji studovány a popisovány, protože je to již nad rámec aktuálního klinického využití. Nalezené genetické změny budou detailně popsány z hlediska jejich možného dopadu na proteinovou strukturu, regulaci signálních drah apod. Výsledky dizertační práce přispějí k rozvoji personalizovaného přístupu k pacientům.

Interestingly, large amounts of gene mutations causing developmental abnormalities, e.g. orofacial diseases are shared with oncological diseases and they were found to be responsible for the induction of carcinogenesis. However, current knowledge of the associations of shared molecular characteristics between orofacial anomalies and carcinogenesis is insufficient. The goal will be to reveal the simultaneous occurrence of orofacial abnormalities and cancer and whether it would be possible to use the shared association of genes and found genetic variants, for example, for the targeted early detection of cancer. Methodologically, the dissertation will mainly deal with the preparation of exome and multigene sequencing libraries, possibly with other methods of analysis of genetic changes. In addition to early cancer screening, the dissertation will deal with interesting genomic changes that are detected during molecular profiling of tumors within the framework of routine predictive examinations. These are, for example, secondary reversion mutations, variants identified in the Kozak sequence, variants in the regions of exon splicing, etc. However, these aberrations are usually not studied and described more deeply, as it is beyond the scope of current clinical use. The genetic changes found will be described in detail in terms of their possible impact on the protein structure, regulation of signaling pathways, etc. The results of the dissertation will contribute to the development of a personalized approach to patients.

Návaznost na projekt AZV ČR, reg. č. NW24-10-00204.
Poznámky

Téma je rezervováno. This topic is reserved.

Školitel

RNDr. Ing. Ondřej Bonczek, Ph.D.

Školitelé

Informace o studiu

Zajišťuje Přírodovědecká fakulta
Typ studia doktorský
Forma prezenční ano
kombinovaná ano
distanční ne
Možnosti studia jednooborově ano
jednooborově se specializací ne
v kombinaci s jiným programem ne
Doba studia 4 roky
Vyučovací jazyk angličtina
Spolupracující instituce
  • Akademie věd ČR
  • Biofyzikální ústav AV ČR
Oborová rada a oborové komise
Poplatky za studium
Studium v cizích jazycích je zpoplatněné, platba je za akademický rok
3 000 EUR
Více informací

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