Blog Grid

1) Praha – Karlova univerzita “Does convergent evolution of molecular phenotypes shape immune responses in birds?”  – V laboratoři https://web.natur.cuni.cz/zoology/eei/– four-year fully funded STARS PhD position in avian evolutionary immunology  – deadline for applications: 13 March 2024 2) Brno – … Read More

Jste v pátém ročníku a koukáte po PhD studiu? Pokud Vás zajímá genetika a imunitní odpověď u ptáků, pak zkuste plně hrazenou pozici v Praze. PhD je vypsáno v rámci projektů STARS program. Přihlášky podávejte do 13. března 2024, očekávaný … Read More

Přijďte si ve čtvrtek 18. ledna poslechnout přednášku prof. Jense Steina o signalizaci T-lymfocytů.

Poslechněte si ve středu 10. ledna od 16h dr. Pavlínu Janovskou (OFIŽ, CasInvent Pharma) v panelové diskuzi, spolu s ostatními hosty nám poodhalí tajemství úspěchu v biotechnologickém podnikání. Na přednášku se registrujte zde.

31. 12. 2023, 19:25 Ohlédnutí za rokem 2023 Milí studenti, kolegové a přátelé, děkujeme Vám všem za přízeň a spolupráci v uplynulém roce! Pro radost přikládáme ohlédnutí za rokem 2023 s tím, co se nám letos nejvíce podařilo a na co jsme pyšní. Přejeme Vám … Read More

Už v červnu vyhrála středoškolská studentka Adriena Jedličková celostátní kolo soutěže SOČ v oboru Biologie a vědy o Zemi (psali jsme zde). Spolu s výhrou tehdy získala také Cenu nadačního fondu Jaroslava Heyerovského, k jejímuž předání došlo nyní, ve středu … Read More

Za své výrazné počiny, publikování v odborných prestižních magazínech a výsledky v oblasti výzkumu sklidili v pondělí 11. prosince ocenění v podobě MUNI SCIENTIST AWARD 2023 nejúspěšnější vědci či výzkumné týmy Masarykovy univerzity. Mezi oceněnými je také Mgr. Peter Fabian, Ph.D., který byl oceněn … Read More

We have a position available in the Department of Molecular Oncology for a highly motivated and independent candidate to investigate intestinal biology and the development of colorectal cancer including the role of oncogenic pathways, tumor stroma, and the immune system … Read More

V pátek 24. listopadu proběhl v prostorách OFIŽ nový kurz pro středoškoláky z cyklu T-exkurzí. Dr. Helena Nejezchlebová vedla kurz „Jak to vidí kyslík“ aneb netradiční exkurze po těle. V kurzu se studenti dozvěděli, kolik je v které tkáni kyslíku … Read More

| 1. 12. 2023, 11:48 OFIŽ: novinky pro prosinec 2023 Milí studenti, kolegové a přátelé, posíláme novinky a zajímavosti pro měsíc prosinec. Přejeme vám všem pohodové Vánoce a co nejsnazší učení se na zkoušky! 🎁🔔 Když byste měli novinku, akci nebo zajímavost, kterou … Read More

Srdečně Vás zveme na přednášku “Elucidating the molecular determinants of vector tropism of bunyaviruses”. Koná se v úterý 21. listopadu od 14h v B11/311. Více o akci se dozvíte zde.

Vývoj biosenzorů pro analýzu nádorových biomarkerů

The new AKTA chromatography system has strengthened our laboratory possibilities and capacities! The first protein purification and extremely immediately successful!

Abstract: Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been … Read More

Abstract: In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and … Read More

For further information, visit this page.

By 30. 04. 2023, you can submit applications for PhD study in our program Animal physiology, immunology and developmental biology – starting from autumn semester 2023. Study Program Summary Interview & Study Requirements Profiles of Our Graduates Submit Application Detailed … Read More

Laboratories of Dr. Konstantinos Tripsianes (CEITEC MU) and Prof. Vítězslav Bryja (Faculty of Science MU) are looking for new colleagues: (i) Research technician workload: 40 hours per week work tasks:  a) general molecular biology tasks: DNA and protein analysis, transformation, … Read More

We cordially invite you to a lecture: Cytonemes in cell signalling – Spreading Wnt signals in development and disease

Srdečně vás zveme na přednášku: Cytonemes in cell signalling – Spreading Wnt signals in development and disease

Abstract: Casein kinases 1 (CK1) are key signaling molecules that have emerged recently as attractive therapeutic targets in particular for the treatment of hematological malignancies. Herein, we report the identification of a new class of potent and highly selective inhibitors … Read More

Abstract: The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression. While the research in immunopathology mostly employed powerful indirect methods such as flow cytometry, these cells were rarely observed … Read More

Abstract: Spontaneous bleeds are a leading cause of death in the pediatric JAG1-related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vascular defects, and whether … Read More

Během listopadu a prosince 2022 proběhly v prostorách OFIŽ dva workshopy v rámci tzv. T-exkurzí. Jedná se o půldenní exkurze pro studenty středních škol z Jihomoravského kraje s hlubším zájmem o vědu, kdy si pod odborným vedením vyzkouší práci vědce nebo studenta VŠ. … Read More

 |  2. 12. 2022, 14:35 OFIŽ: novinky pro prosinec 2022 Milí studenti, kolegové a přátelé OFIŽ, se začátkem dalšího měsíce se k vám dostává další newsletter OFIŽ, ve kterém vám chceme dát vědět, co je u nás nového, které příležitosti byste neměli minout … Read More

Abstract: Over the past decades an extensive effort has been made to provide a more comprehensive understanding of Wnt signaling, yet many regulatory and structural aspects remain elusive. Among these, the ability of Dishevelled (DVL) protein to relocalize at the … Read More

AbstractThe extensive annual loss of honey bees (Apis mellifera L.) represents a global problem affecting agriculture and biodiversity. The parasitic mite Varroa destructor, associated with viral co-infections, plays a key role in this loss. Despite years of intensive research, the … Read More

This year, the Grant Agency of the Czech Republic (GACR) will support 23 projects as part of the Junior STAR challenge, two of which go to Masaryk University. One of the supported researchers is our dr. Peter Fabian, who received … Read More

 |  3. 10. 2022, 7:36 OFIŽ: novinky pro říjen 2022 Milí studenti, kolegové a přátelé OFIŽ, se začátkem nového semestru se vracíme k publikování měsíčního newsletteru OFIŽ, ve kterém vám chceme dát vědět, co je u nás nového, které příležitosti byste neměli minout … Read More

Abstract: The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the … Read More

On Friday and Saturday, May 13 – 14, the Signalling In Development and Disease conference took place at the Kocanda hotel in Želiv in the Českomoravská Vysočina area. Key speakers were Andreas Moor (ETH Basel) and Emma R. Andersson (KI … Read More

Abstract: Luciferase reporter assays represent a simple and sensitive experimental system in cell and molecular biology to study multiple biological processes. However, the application of these assays is often limited by the costs of conventional luminometer instruments and the versatility … Read More

Abstract: In temperate climates, honey bee workers of the species Apis mellifera have different lifespans depending on the seasonal phenotype: summer bees (short lifespan) and winter bees (long lifespan). Many studies have revealed the biochemical parameters involved in the lifespan … Read More

Abstract: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic … Read More

The aim of this award is to increase the number of doctoral students who complete their studies in the standard study period, possibly extended by one year, with excellent results processed in their dissertation. The award should motivate students and … Read More

Read the interview with assoc. prof. Milan Číž on November 17, 1989, his memories of this period, when he had been completing his diploma thesis at PřF MUNI and then had began his career as a scientist. In the interview, … Read More

The latest article from the laboratory of assoc. prof. Buchtová was already successful even at the very beginning of its publication and was selected for the cover of a new issue of the Journal of Bone and Mineral Research! Congratulations! … Read More

On the occasion of the Business Research Forum – the trade fair for cooperation between Masaryk University and business field, Masaryk University awarded the exceptional innovative achievements of its researchers. Masaryk University awarded achievements in research that have been successfully … Read More

We would like to cordially invite you to a talk by Marek Mlodzik, a leading expert in the field of Wnt/PCP signaling: Marek Mlodzik – Icahn School of Medicine at Mount Sinai, USA Prof. Marek Mlodzik will give his talk Wnt/Frizzled … Read More

Invitation to the talk by Prof. Nissim Benvenisty We cordially invite you to the lecture: „The Essentialome of Human Pluripotency”by Prof. Nissim Benvenisty, The Azrieli Center for Stem Cells and Genetic Research, The Hebrew University of Jerusalem WHEN: Tuesday, October … Read More

The Neuron Endowment Fund awarded the Neuron Prizes on Tuesday, September 28, in the Pantheon of the National Museum. The awards were given in the categories of lifelong contribution to science, young promising scientists and for the first time, also … Read More

By 30. 11. 2021, you can submit applications for PhD study in our program Animal physiology, immunology and developmental biology – starting from spring semester 2022. Study Program Summary Interview & Study Requirements Profiles of Our Graduates Submit Application Detailed … Read More

We are already making full use of the newly accredited Danio rerio fish farming facility!  Mgr. Michaela Nosková from the group of prof. Bryja works with their embryos, into which she will then inject tumor cells. This will allow her to … Read More

Thanks to the confocal microscope, we can observe the cells really closely! Take a look at a photograph of cells on which actin, a part of the cytoskeleton of cells, is highlighted with phalloidin. The confocal microscope can capture the … Read More

Abstract: The aim of this study was to investigate the effects of three commercial diets, standard, immunostimulant-supplemented (β-glucan, vitamins C and E) and plant-based, on the degree of oxidative stress in tissues of rainbow trout (Oncorhynchus mykiss). Selected immune and … Read More

Abstract: WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often … Read More

Abstract: Laser-induced plasma (LIP) is dependent on many experimental conditions, as well as on the material and type of the ablated sample. Typically, the spectral data from a LIP are used as an analytical tool. However, the problem is that … Read More

We enclose offers for interesting job positions in the field!

Abstract: The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays … Read More

Our students succeeded with their research work and received the Dean’s Award! Congratulations to all and thank you for the great representation of the OFIŽ! 🍀👏   In the category of the best students of bachelor’s and master’s programs, the … Read More

We cordially invite you to PhD defenses of Lenka Radoňová & Petra Paclíková that will take place on Friday 18. 6. 2021 at 9:00 at the University Campus Bohunice B11/235. Schedule: Current regulations for meetings in person: To be allowed … Read More

Abstract: Dishevelled (DVL) proteins are key mediators of most Wnt pathways. In all vertebrates, three DVL paralogs are present (DVL1, DVL2 and DVL3) but it is poorly defined to what extent they are functionally redundant. Here, we generated T-REx HEK … Read More

We cordially invite to the 4th Czech Cilia Meeting that will take place on 30. 8. 2021 at the University Campus Bohunice:

Abstract: Achondroplasia is the most prevalent genetic form of dwarfism in humans and is caused by activating mutations in FGFR3 tyrosine kinase. The clinical need for a safe and effective inhibitor of FGFR3 is unmet, leaving achondroplasia currently incurable. Here, … Read More

Our article about seasonal changes of honey bee physiological and immune parameters is now listed in Atlas of Science.

We cordially invite you to 11th International Conference Analytical Cytometry, that will take place on 2. – 5. 10. 2021 in Ostrava:

Abstract: The improving performance of the laser-induced breakdown spectroscopy (LIBS) triggered its utilization in the challenging topic of soft tissue analysis. Alterations of elemental content within soft tissues are commonly assessed and provide further insights in biological research. However, the … Read More

Abstract: The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development. Here, we … Read More

Abstract: The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. Authors: Neil Dani … Read More

Bryjalab has recently achieved several successes in their research on Wnt signaling and the choroid plexus!  /choroid plexus is a tissue in brain that produces most of the cerebrospinal fluid of the central nervous system/ A collaborative publication – in … Read More

Dr. Jakub Harnoš has received the prestigious MUNI Award in Science and Humanities (MASH) JUNIOR! This award aims to create stable conditions for young promising researchers shortly after PhD to establish or develop their own research group and seek further … Read More

Research group of Assoc. Prof. Pavel Hyršl continues with the collection of bees within research projects supported by the Ministry of Agriculture. After overwintering, they found bees marked in experimental hives in the autumn, and this year they continue to … Read More

Abstract: Overwintering is a challenging period in the life of temperate insects. A limited energy budget characteristic of this period can result in reduced investment in immune system. Here, we investigated selected physiological and immunological parameters in laboratory-reared and field-collected … Read More

Abstract: Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β. However, gaps exist in our understanding of how cilia formation and function is … Read More

Abstract: Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture … Read More

Studentky OFIŽ zaznamenaly velký úspěch v soutěži Brno Ph.D. Talent pořádané sdružením JCCM a.s. Brno Ph.D. Talent je prestižní soutěž pro mladé vědecké talenty z brněnských univerzit s cílem podpořit začínající doktorandy. Celková stipendijní podpora činí 300 000 na tři … Read More

Abstract: In the temperate climates of central Europe and North America, two distinct honeybee (Apis mellifera) populations are found in colonies: short-living summer bees emerge in spring and survive until summer, whereas long-living winter bees emerge in late August and … Read More

Faculty of Science MUNI has recently prepared an interview with Vita Bryja as a part of “Success Stories” series of scientists at the faculty.

Abstract: The PDZ domain of Dishevelled 3 protein belongs to a highly abundant protein recognition motif which typically binds short C-terminal peptides. The affinity of the PDZ towards the peptides could be fine-tuned by a variety of post-translation modifications including … Read More

Dear students, we posted an updated table on the PhD study requirements – we corrected the information for the course C7777: Handling chemical substances. This course needs to be completed in each autumn semester of your study, not just during … Read More

Abstract: Novel composite films combining biocompatible polysaccharides with conducting polyaniline (PANI) were prepared via the in-situ polymerization of aniline hydrochloride in the presence of sodium hyaluronate (SH) or chitosan (CH). The composite films possess very good cytocompatibility in terms of … Read More

Abstract: The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to … Read More

Abstract Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where … Read More

Abstract Hybrid advantage, described as the superiority of hybrids in some traits over their parents and termed the “heterosis effect,” is widely documented in the case of reciprocal crosses of parental species (i.e., hybrids representing the F1 generation). In fish, … Read More

We are happy to announce that, from the next academic year (2021/2022), it will be possible to study Molecular and Cell Biology at our faculty in English! You can apply for this program of follow-up Master’s studies from 1 January … Read More

V únoru čeká doktorské studenty ve 3. semestru PhD Workshop, kde přednesou prezentaci s hypotézami a výsledky svého PhD projektu. Termín: 19. 2. 2021 Forma: online (pokud se situace změní, budeme včas informovat)

A new spin-off company, CasInvent Pharma, a.s., has been established by Masaryk University (MU) in cooperation with its investment partner, i&i Prague, s.r.o. (Ltd), in order to facilitate further development of new compounds that could be used to treat certain … Read More

Selected scientists from Masaryk University were awarded for their outstanding research results and significant achievements in the field of research from 2019 to 2020 by the Vice-Rector for Research and Doctoral Studies prof. Šárka Pospíšilová. Later, they have managed to … Read More

Dietary supplementation with polyunsaturated fatty acids (PUFA) n-3 can affect cutaneous wound healing; however, recent findings demonstrate the variable extent of their influence on the quality of healing. Here, we compare the effect of several dietary oils, containing different levels … Read More

The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. … Read More

The inhalation of metal (including lead) nanoparticles poses a real health issue to people and animals living in polluted and/or industrial areas. In this study, we exposed mice to lead(II) nitrate nanoparticles [Pb(NO3)2 NPs], which represent a highly soluble form … Read More

Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders often affecting skeletal development. This includes Jeune syndrome or asphyxiating thoracic dystrophy (ATD), an autosomal recessive skeletal disorder. Unraveling the responsible molecular pathology helps illuminate mechanisms responsible … Read More

The group led by assoc. prof. Pavel Hyršl recently marked several thousands of winter bees. In the laboratory, they will then investigate how bee immunity responds to specific stress conditions.The marking of bees took place at the Bee Research Institute, … Read More

12-O-Tetradecanoylphorbol-13-acetate (TPA) is the most widely used diacylglycerol (DAG) mimetic agent and inducer of protein kinase C (PKC)-mediated cellular response in biomedical studies. TPA has been proposed as a pluripotent cell differentiation factor, but results obtained have been inconsistent. In … Read More

Conducting polymers (CP) can be used as pH- and/or electro-responsive components in various bioapplications, for example, in 4D smart scaffolds. The ability of CP to maintain conductivity under physiological conditions is, therefore, their crucial property. Unfortunately, the conductivity of the … Read More

Assoc. Prof. Marcela Buchtová, together with Lenka Doubková, Nikodém Zezula and Pavel Dobeš, successfully fought the demanding accreditation process and endless forms, and OFIŽ thus finally obtained permission from the Ministry of Agriculture for breeding and experimental use of fish, … Read More

At our department, Alena Hyršlová Vaculová and Martin Anger successfully defended their habilitation theses and received the new academic titles of Associate Professors. Congratulations! Assoc. Prof. RNDr. Alena Hyršlová Vaculová, Ph.D. Associate Professor Alena Hyršlová Vaculová obtained a habilitation in … Read More

Dear Colleagues, Insect pathogenic nematodes (entomopathogenic nematodes—EPNs) are lethal parasites to their hosts, and are frequently used as biological agents in the control of insect pests. Lethality may be as a result of the virulence factors provided by the nematodes … Read More

Individuals reared in captivity are exposed to distinct selection pressures and evolutionary processes causing genetic and phenotypic divergence from wild populations. Consequently, restocking with farmed individuals may represent a considerable risk for the fitness of free-living populations. Supportive breeding on … Read More

Dear colleagues, students and friends, we cordially invite you to doctoral defenses of our students – Marek Hampl (M. Buchtová’s laboratory) and Tomasz Radaszkiewicz (V. Bryja’s laboratory), which take place on Monday, 31.8.2020 in classroom A11/306 at 10:20, resp. 14.00:

Students from the Laboratory of Molecular Morphogenesis led by assoc. prof. Marcela Buchtová prepared an embryology workshop for high school students. The students first observed the different developmental stages of the chicken embryos and tried to recognize and identify them. … Read More

Secondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary … Read More

The group led by assoc. prof. Pavel Hyršl breeds silkworms again! They use the silkworms (Bombyx mori) as one of their model organisms for research. Over time, silkworm caterpillars pupate and turn into a silk moth.

A comprehensive review on choroid plexus and its regulatory role in CNS by Karol Kaiser, Ph.D. just published in International Journal of Molecular Sciences! Follow us on Twitter. 😉

O‐methylation is an unusual sugar modification with a function that is not fully understood. Given its occurrence and recognition by lectins involved in the immune response, methylated sugars were proposed to represent a conserved pathogen‐associated molecular pattern. We describe the … Read More

Objectives:The aim of this study is to evaluate the seroprevalence of antibodies of Borrelia burgdorferi sensu lato (Bbsl) and Leptospira interrogans sensu lato (Lisl) and their possible concurrence in domestic cats living in variable conditions in South Moravia in the … Read More

Another paper out and another step closer to a better understanding of #RNF43 tumor #suppressor action thanks to Tomek Radaszkiewicz from Bryjalab!   Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells … Read More

Another paper out and another step closer to a better understanding of #RNF43 tumor #suppressor action thanks to Tomek Radaszkiewicz!   Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells Cell Commun … Read More

Students of our department succeeded with their work and received the Dean’s Awards! Congratulations to all & thank you for the great representation of the department! In the category of the best students of bachelor’s and master’s programs: Mgr. Tomáš … Read More

Assoc. Prof. Alena Žákovská gave an interview to the iDnes.cz and shared her experience with the current occurrence of ticks in Brno, which she regularly monitors using so-called “flagging”. The rainy weather that has prevailed in recent weeks provides an … Read More

ABSTRACT: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of the cell surface receptor ROR1. Both, BCR and ROR1 are therapeutic targets in … Read More

Stem Cell Res. 2020 May;45:101770 ABSTRACT: Embryonic neural stem cells (NSCs), comprising neuroepithelial and radial glial cells, are indispensable precursors of neurons and glia in the mammalian developing brain. Since the process of neurogenesis occurs in a hypoxic environment, the … Read More

Insects 2020, 11(6), 353; https://doi.org/10.3390/insects11060353 ABSTRACT: Entomopathogenic nematodes (EPNs) are efficient insect parasites, that are known for their mutualistic relationship with entomopathogenic bacteria and their use in biocontrol. EPNs produce bioactive molecules referred to as excreted/secreted products (ESPs), which have … Read More

Elsevier Collection of Neuroscience and Biobehavioral Psychology, https://doi.org/10.1016/B978-0-12-809324-5.24159-X ABSTRACT: The discovery of magnetic sensitivity in invertebrates such as Drosophila, the cockroach Periplaneta americana, or the nematode Caenorhabditis elegans make us reconsider our intuitive and possibly too anthropocentric views about the … Read More

Development 2020 147: dev186338 ABSTRACT: Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay … Read More

Helena Modra, Miroslava Palikova, Pavel Hyrsl, Jana Bartonkova, Ivana Papezikova, Zdenka Svobodova, Jana Blahova, Jan Mares The aim of this study was to assess the effects of T-2 toxin–contaminated feed (at concentrations of 1.0 and 1.8 mg/kg) on the rainbow … Read More

ABSTRACT: Bumble bees are important pollinators broadly used by farmers in greenhouses and under conditions in which honeybee pollination is limited. As such, bumble bees are increasingly being reared for commercial purposes, which brings into question whether individuals reared under … Read More

Just posted: MEIS-Wnt5a axis revealed as regulator of choroid plexus development ABSTRACT: The choroid plexus (ChP) produces cerebrospinal fluid and forms a critical barrier between the brain and the circulation. While the ChP forms in each brain ventricle, it adopts … Read More

Cells 2020, 9(5), 1147. ABSTRACT Wnt and BMP signaling pathways are two key molecular machineries regulating development and homeostasis. The efficient coordination of Wnt and BMP is essential in many developmental processes such as establishment of antero-posterior and dorso-ventral body … Read More

For beekeepers, it is important to know what proportion of long-lived bees are in the bee population already at the beginning of autumn, because this fact decides whether or not the bee population will survive the winter. Unfortunately, these two … Read More

PLoS One. 2020 Mar 25;15(3):e0229170. doi: 10.1371/journal.pone.0229170. ABSTRACT: Surface protein CD20 serves as the critical target of immunotherapy in various B-cell malignancies for decades, however its biological function and regulation remain largely elusive. Better understanding of CD20 function may help … Read More

The number of applications for the bachelor study of Experimental Animal Biology and Immunology increased from 329 in 2019 to 348 this year, and above all, the number of applications in which the applicants chose us as the first preferred … Read More

Lead oxide nanoparticles (PbONPs), upon their entry into the lungs via inhalation, induce structural changes in primary and secondary target organs. The fate and ultrastructural localization of PbONPs in organs is known to be dependent on the specific organ. Here, … Read More

PhD thesis of Mgr. Pavlína Janovská, Ph.D. was ranked among the 13 most successful dissertations in the Werner von Siemens 2019 competition! This year, 645 applications for diploma and doctoral theses entered the competition, so Pavlina’s placement is a truly … Read More

Our graduate Mgr. Michaela Gregorova has published an article in the new issue of Živa magazine, a popular scientific journal bringing contributions from biological disciplines. Míša published her article “The future in the treatment of chronic lymphocytic leukemia? Inhibition of … Read More

Mgr. Tomáš Gybel´, a doctoral student from the laboratory of prof. Vitezslav Bryja, won the prestigious Brno PhD Talent 2019 scholarship! Tomáš succeeded with his PhD project “Molecular and Functional Analysis of Casein Kinase 1 Biology”.  The scholarship is awarded … Read More

Pavlina Janovska, Ph.D. has been chosen in the selection of noteworthy women scientists at MUNI on the occasion of The International Day of Women and Girls in Science (the 11th day of February) announced by United Nations. Congratulations! See the … Read More

We would like to cordially invite you to the lecture:

Students of our department have succeeded in the grant competition of the Rector Program!Grants are awarded to outstanding students of Master’s degree programs for research related to their thesis.Congratulations!   The following students received support for their projects: Bc. Eliška … Read More

In recent days, we participated in the Open Days at Masaryk University.Thank you for your interest and we wish you all a lucky choice of your study field at the university!

Hanáková K, Bernatík O, Kravec M, Micka M, Kumar J, Harnoš J, Ovesná P, Paclíková P, Rádsetoulal M, Potěšil D, Tripsianes K, Čajánek L, Zdráhal Z, Bryja V. BACKGROUND: Dishevelled (DVL) is an essential component of the Wnt signaling cascades. … Read More

High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is the deadliest gynecological disease which results in a five-year survival rate of 30% or less. HGSC is characterized by the early and rapid development of metastases accompanied by … Read More

BACKGROUND: In mammals, odontogenesis is regulated by transient signaling centers known as enamel knots (EKs), which drive the dental epithelium shaping. However, the developmental mechanisms contributing to the formation of complex tooth shape in reptiles are not fully understood. Here, … Read More

Students of our department took first places in the competition for the best works focused on Lyme disease. The award was given by the Borelioza.cz association, which also supports research on this disease. Bc. Soňa Ševelová (supervisor Dr. Helena Nejezchlebová) … Read More

Although the production of engineered nanoparticles increases our knowledge of toxicity and mechanisms of bioactivity during relevant exposures is lacking. In the present study, mice were exposed to PbO nanoparticles (PbONP; 192.5 µg/m3; 1.93 × 106 particles/cm3) for 2, 5 and 13 weeks through … Read More

We would like to cordially invite you for the habilitation lecture of MVDr. Martin Anger, CSc. Control Mechanisms of Chromosome Segregation at the Onset of Mammalian Development WHEN: Friday, 1. 11. 2019 at 10.00 WHERE: A11/306 part of the PhD … Read More

BACKGROUND: The egg tooth is a vital structure allowing hatchlings to escape from the egg. In squamates (snakes and lizards), the egg tooth is a real tooth that develops within the oral cavity at the top of the upper jaw. … Read More

Have a look at the interview with prof. Vítězslav Bryja for the Neuron Fund for Support of Science, which explains prof. Bryja´s research in a clear and very nice way. The interview was created as a part of „Scientists under … Read More

It is known that the circadian clock in Drosophila can be sensitive to static magnetic fields (MFs). Man-made radiofrequency (RF) electromagnetic fields have been shown to have effects on animal orientation responses at remarkably weak intensities in the nanotesla range. … Read More

On Friday, September 28, 2019, we took part in the Researchers’ Night at Masaryk University!We were pleased by the number of visitors, we were happy to show the most interesting treasures that are hidden in our laboratories!We look forward to … Read More

Congratulations to Martin Vácha who was awarded for the best presentation at spring PI seminar organized by Ceitec! Martin Vácha impressed the audience with his lecture entitled “Magnetic Clocks and Photosensitive Compasses: Puzzling Cryptochromes”. You can read more about Martin … Read More

This week, assoc. prof. Alena Žákovská hosted dr. hab. prof. Dorota Kiewra who arrived from the University of Wroclaw to share her experience regarding the infectivity and geographic distribution of ticks. Dr. hab. prof. Dorota Kiewra gave a lecture entitled … Read More

At the beginning of the semester, we introduced our department to students who are interested in studying at Faculty of Science at Masaryk University. If you couldn’t visit us, don’t worry! Information materials are available online – students looking for … Read More

We attended the workshop Frontiers in insect physiology!

We attended the conference International Congress on Invertebrate Pathology and Microbial Control & 52nd Annual Meeting of the Society for Invertebrate Pathology & 17th Meeting of the IOBC‐WPRS Working Group “Microbial and Nematode Control of Invertebrate Pests”.

It has been known for many years that in temperate climates the European honey bee, Apis mellifera, exists in the form of two distinct populations within the year, short-living summer bees and long-living winter bees. However, there is only limited … Read More

Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development, we employed gene trap knock-out … Read More

Masaryk University Technology Transfer Office prepared an interview with Vitezslav Bryja about developing inhibitors of casein kinase 1 in collaboration with Kamil Paruch´s group (Department of Chemistry) that can be used in the future as treatment of chronic lymphocytic leukemia … Read More

Congratulations to a former student of our dept. Ján Remšík, PhD who was included in the prestigious list of 30 young successful Slovaks under age of 30 by Forbes Magazine! Now, Ján Remšík continues with research in the Adrienne Biore … Read More

On Saturday we celebrated the Alumni Day of Masaryk University! Thank you all for coming & see you soon again!

Students of our dept. received the Dean´s award for their high-level theses & publication successes! Good job! We wish you a lot of success in your further research!   Awards for outstanding diploma thesis: Michaela Gregorová: Novel casein kinase 1 … Read More

Congratulations to our high school students who succeeded in the region level of Students´ Professional Activities national contest (SOČ)! Thank you for your perfect representation & good luck in your further work! Martin Zavřel Zuzana Ševčíková Kateřina Kudličková Sára Tučková … Read More

Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL … Read More

Almost fifty participants met on May 23, 2019 in one of the lecture halls of the Brno University Campus at a workshop focused on topics connected with ticks. A wide spectrum of visitors listened for more than 3 hours to … Read More

See the unique start-up opportunity at Masaryk University! MUNI Award in Science and Humanities (MASH): https://gamu.muni.cz/en/mash Our department can accommodate the MASH holder. Please contact Vitezslav Bryja directly at bryja@sci.muni.cz for info if you are expert in immunology/cell/developmental biology and … Read More

Pavel Hyršl as an expert on bees and their life gave an interview to the Czech television on occasion of the World Bee Day – 20th May 2019. See the interview here: https://www.ceskatelevize.cz/porady/10435049455-dobre-rano/319291310020047/video/697290,697297,697307

Congratulations! Pavlina Janovska, Ph.D. received the rector´s award for outstanding scientists under age of 35 at Masaryk University! Pavlina´s research is focused on CK1 inhibitors and treatment of chronic lymphocytic leukemia, see her publication list here: http://bit.ly/2JmGtc2! See video from … Read More

Today, it is Vita Bryja´s honor to host one of the key inventors of the CRISPR–Cas9 technology – Prof. Emmanuelle Charpentier (Max Planck Unit for the Science of Pathogens, Germany), who is visiting our lab and giving a Mendel lecture “CRISPR-Cas9: a … Read More

Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhibit signaling through … Read More

Follow this link (in czech): Czech TV

Congratulations to our student Kacka Kudlickova! Thanks to Kacka´s great success in Healthcare category of Students´ Professional Activities national contest (SOČ) where she won the 2nd place, now she has been chosen to represent the Czech Republic in the international contest Beijing … Read More

We cordially congratulate to Jakub Harnoš, Ph.D. who has successfully completed his journey to a doctoral degree!And we wish him the BEST OF LUCK in his new postdoc position in New York in Sergei Sokol´s laboratory!

Last week, Masaryk University had the honor to host Prof. Rudolf Jaenisch, who created the first transgenic animal model in history (see Prof. Jaenisch´s biography here). Prof. Rudolf Jaenisch also visited our lab and gave a lecture “Epigenetic Regulation in Development, Aging and … Read More

Last week, Masaryk University had the honor to host the Nobel Prize laureate, Prof. Eric F. Wieschaus, who was awarded the Nobel Prize (1995) in the field of Physiology with Edward B. Lewis and Christiane Nüsslein-Volhard as co-recipients, for their work revealing … Read More

To see the video, follow this link (in czech): Czech TV

Congratulations to Pavlína Janovská who won the 3rd place in competition SANOFI PRIZE FOR PHARMACY 2018 whose purpose is to award the best PhD research works in experimental biomedical and pharmaceutical research! Pavlina´s great success was noticed by several media: ibrno.cz denik.cz … Read More

Congratulations to Kristína Gömöryová who successfully obtained a Master’s degree and was admitted to PhD study! And congratulations also to our new bachelors who smoothly defended their theses! Miroslav Micka, Nikodém Zezula, Štěpán Čada, Jana Lapinová, Petra Kompaníková

Congratulations to our student Kacka Kudlickova! She won the second place in Healthcare category of Students´ Professional Activities national contest (SOC – Středoškolská odborná činnost)!

Two articles – about czech science and career in science and family life (with contribution of Vita Bryja), were published in Universitas magazine (in czech only): Universitas: Anketa: Co je na české vědě špatně? A jak tu udržet mladé? Universitas: … Read More

We are more than happy that we helped our boss to dig manually the greatest hole in the world #CestaDoStreduZeme #VybagrujteCechy,SlovenskoChceMore #ZerykInLove

By: Eva Krkavcová, Jakub Kreisinger, Ludmila Hyánková, Pavel Hyršl, Veronika Javůrková Published in: Open Biology ABSTRACT Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it … Read More

By Barbora Šafránková, Martina Hermannová, Kristina Nešporová, Vladimír Velebný, and Lukáš Kubala Published in: International Journal of Biological Macromolecules Abstract Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells … Read More

Michal KNAPP1, Pavel DOBEŠ2, Michal ŘEŘICHA1, Pavel HYRŠL2 1 Department of Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic; e-mails: knapp@fzp.czu.cz, rericham@fzp.czu.cz 2 Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty … Read More